Literature DB >> 8298081

Lithium enhances 5-HT2A receptor-mediated c-fos expression in rat cerebral cortex.

R A Leslie1, J M Moorman, D G Grahame-Smith.   

Abstract

The role of lithium in treating bipolar affective disorder is poorly understood; however, it may involve effects on brain 5-HT function. We have shown that the 5-HT2A/2C receptor agonist DOI (2,5-dimethoxy-4-iodophenylisopropylamine) induces the expression of c-fos in rat brain which correlates with the distribution of 5-HT2A receptors. We now report on the effect of lithium on 5-HT receptor activation. Rats were treated chronically with dietary lithium before being given either DOI or the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), and their brains were processed for c-fos immunohistochemistry. Lithium treatment greatly enhanced levels of Fos seen after DOI, but not after 8-OH-DPAT; layer II of caudal piriform cortex, previously devoid of staining, exhibited the most marked labelling. This suggests that chronic lithium selectively alters immediate-early gene expression in brain. Such alteration may underlie the action of lithium in treating bipolar affective disorder.

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Year:  1993        PMID： 8298081     DOI： 10.1097/00001756-199312000-00014

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons.

Authors:  J L Scruggs; S Patel; M Bubser; A Y Deutch
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

2.  5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells.

Authors:  L D Van de Kar; A Javed; Y Zhang; F Serres; D K Raap; T S Gray
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

3.  Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes.

Authors:  J-D Guo; S E Hammack; R Hazra; L Levita; D G Rainnie
Journal:  Neuroscience       Date:  2009-09-22       Impact factor: 3.590

4.  Role of G(q) protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane.

Authors:  Efrain E Garcia; Randy L Smith; Elaine Sanders-Bush
Journal:  Neuropharmacology       Date:  2007-04-04       Impact factor: 5.250

5.  Ebselen has lithium-like effects on central 5-HT2A receptor function.

Authors:  I Antoniadou; M Kouskou; T Arsiwala; N Singh; S R Vasudevan; T Fowler; E Cadirci; G C Churchill; T Sharp
Journal:  Br J Pharmacol       Date:  2018-05-22       Impact factor: 8.739

6.  The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex.

Authors:  M M Menezes; M A Santini; M J Benvenga; G J Marek; K M Merchant; J D Mikkelsen; K A Svensson
Journal:  Neurosci J       Date:  2013-11-19

Review 7.  What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders.

Authors:  Jayme R McReynolds; John P Christianson; Jordan M Blacktop; John R Mantsch
Journal:  Neurobiol Stress       Date:  2018-06-02
  7 in total

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