Literature DB >> 8297578

Influence of cocaine and lidocaine on human nasal cilia. Beat frequency and harmony in vitro.

K J Ingels1, M R Nijziel, K Graamans, E H Huizing.   

Abstract

The effects of cocaine and lidocaine on ciliary beat frequency and ciliary beat harmony were studied in biopsy specimens of normal human nasal mucosa. Cocaine was investigated in increasing concentrations (0.875%, 1.75%, 3.5%, and 7%) in five samples; lidocaine (0.125%, 0.25%, 0.5%, 1%, and 2%), in four samples. Ciliary beat was recorded photoelectrically and the signal was analyzed. Cocaine was found to decrease ciliary beat frequency and ciliary beat harmony at concentrations of 1.75% and higher. Partially reversible ciliostasis was seen at 7%. Lidocaine was found to decrease ciliary beat frequency and ciliary beat harmony at concentrations of 0.25% and higher. Irreversible ciliostasis was seen at 2%. Cocaine and lidocaine affected ciliary beat frequency and ciliary beat harmony in the same way.

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Year:  1994        PMID： 8297578     DOI： 10.1001/archotol.1994.01880260067012

Source DB:  PubMed          Journal:  Arch Otolaryngol Head Neck Surg        ISSN： 0886-4470


  9 in total

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4.  The endoscopic study of human middle ear mucociliary transport.

Authors:  Jaana H Ilomäki; T Karhuketo; J P Vasama; J Kääriäinen; M Rautiainen
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-07-30       Impact factor: 2.503

5.  Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time.

Authors:  J Zabner; B G Zeiher; E Friedman; M J Welsh
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

6.  Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells.

Authors:  Alexander Nastev; J Ulrich Sommer; Wieland Behr; Boris A Stuck; C Emika Mueller; Angela Schell; Benedikt Kramer; Daniel Haeussler; Karl Hoermann; Richard Birk
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7.  Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis.

Authors:  J Zabner; B W Ramsey; D P Meeker; M L Aitken; R P Balfour; R L Gibson; J Launspach; R A Moscicki; S M Richards; T A Standaert
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8.  Differential effect of anesthetics on mucociliary clearance in vivo in mice.

Authors:  Kyle S Feldman; Eunwon Kim; Michael J Czachowski; Yijen Wu; Cecilia W Lo; Maliha Zahid
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Review 9.  Mucociliary dysfunction in HIV and smoked substance abuse.

Authors:  Srinivasan Chinnapaiyan; Hoshang J Unwalla
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  9 in total

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