Literature DB >> 8297381

The ryanodine receptor from canine heart sarcoplasmic reticulum is associated with a novel FK-506 binding protein.

A P Timerman1, T Jayaraman, G Wiederrecht, H Onoue, A R Marks, S Fleischer.   

Abstract

We find that the purified ryanodine receptor/calcium release channel (CRC) isolated from canine heart sarcoplasmic reticulum (SR) is tightly associated with an FK-506 binding protein which is distinct from human recombinant FKBP-12. Fractions from both skeletal and heart muscle were probed by Western Blot analysis using sequence specific antibody raised against the N-terminus of human recombinant FKBP-12. Only FKBP-12 was detected in rabbit and dog skeletal muscle SR as well as in dog heart cytosol. Canine heart SR and the purified canine heart ryanodine receptor contained an immunoreactive band with a somewhat slower relative mobility than that of human recombinant FKBP-12. These observations indicate that the association between the cardiac CRC and this novel FK-506 binding protein is specific.

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Year:  1994        PMID： 8297381     DOI： 10.1006/bbrc.1994.1101

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  26 in total

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8.  Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads.

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Review 9.  Calcium cycling proteins and heart failure: mechanisms and therapeutics.

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10.  In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6.

Authors:  Christopher H George; Rina Sorathia; Benedicte M A Bertrand; F Anthony Lai
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