| Literature DB >> 8296905 |
E Hollander1, D J Stein, C M DeCaria, L Cohen, J B Saoud, A E Skodol, D Kellman, L Rosnick, J M Oldham.
Abstract
Twelve patients with borderline personality disorder and 15 healthy comparison subjects were challenged with single doses of oral m-chlorophenylpiperazine (m-CPP) and placebo. Following m-CPP, the patients experienced decreased anger and fear. Seven of the 12 patients reported a "spacy," "high," depersonalized/derealized experience following m-CPP, which was confirmed by clinicians' ratings. Compared with the normal male subjects, the male patients with borderline personality disorder had higher cortisol levels and marginally blunted prolactin responses after receiving m-CPP. These results suggest serotonergic dysfunction in borderline personality disorder.Entities:
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Year: 1994 PMID： 8296905 DOI： 10.1176/ajp.151.2.277
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112