Literature DB >> 8296900

Imipramine antagonism of the panicogenic effects of cholecystokinin tetrapeptide in panic disorder patients.

J Bradwejn1, D Koszycki.   

Abstract

Eleven panic disorder patients who panicked in response to exogenous cholecystokinin tetrapeptide (CCK-4) were rechallenged after chronic treatment with imipramine. In the rechallenge the patients displayed a marked reduction in the number and intensity of panic symptoms, duration of symptoms, frequency of panic attacks, and cardiovascular responsiveness. This study demonstrates that imipramine can antagonize the panicogenic effects of CCK-4.

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Year:  1994        PMID： 8296900     DOI： 10.1176/ajp.151.2.261

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN： 0002-953X            Impact factor:   18.112


  15 in total

Review 1.  The genetics of panic disorder.

Authors:  C T Finn; J W Smoller
Journal:  Curr Psychiatry Rep       Date:  2001-04       Impact factor: 5.285

Review 2.  Amine neurochemistry and aggression in crayfish.

Authors:  Jules B Panksepp; Zhaoxia Yue; Catherine Drerup; Robert Huber
Journal:  Microsc Res Tech       Date:  2003-02-15       Impact factor: 2.769

Review 3.  Translational research in central nervous system drug discovery.

Authors:  Orest Hurko; John L Ryan
Journal:  NeuroRx       Date:  2005-10

4.  Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder.

Authors:  J Shlik; A Aluoja; V Vasar; E Vasar; T Podar; J Bradwejn
Journal:  J Psychiatry Neurosci       Date:  1997-11       Impact factor: 6.186

Review 5.  [Experimental provocation of panic attacks as a human experimental model for anxiety].

Authors:  A Ströhle
Journal:  Nervenarzt       Date:  2003-09       Impact factor: 1.214

6.  Cholecystokinin and psychiatric disorders : role in aetiology and potential of receptor antagonists in therapy.

Authors:  J Shlik; E Vasar; J Bradwejn
Journal:  CNS Drugs       Date:  1997-08       Impact factor: 5.749

7.  Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers.

Authors:  Daniela Eser; Gregor Leicht; Jürgen Lutz; Stephan Wenninger; Valerie Kirsch; Cornelius Schüle; Susanne Karch; Thomas Baghai; Oliver Pogarell; Christine Born; Rainer Rupprecht; Christoph Mulert
Journal:  Hum Brain Mapp       Date:  2009-02       Impact factor: 5.038

8.  Tryptophan depletion does not modify response to CCK-4 challenge in patients with panic disorder after treatment with citalopram.

Authors:  Innar Tõru; Jakov Shlik; Eduard Maron; Veiko Vasar; David J Nutt
Journal:  Psychopharmacology (Berl)       Date:  2006-03-16       Impact factor: 4.530

9.  Modelling anxiety in humans for drug development.

Authors:  Martin Siepmann; Peter Joraschky
Journal:  Curr Neuropharmacol       Date:  2007-03       Impact factor: 7.363

10.  Failure of CCK receptor ligands to modify anxiety-related behavioural suppression in an operant conflict paradigm in rats.

Authors:  D Charrier; L Dangoumau; A J Puech; M Hamon; M H Thiébot
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530
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