| Literature DB >> 8296674 |
K M Dolman1, B A van de Wiel, C M Kam, J E Kerrigan, C E Hack, A E von dem Borne, J C Powers, R Goldschmeding.
Abstract
Reactivity of proteinase 3 (PR3) was tested against various amino acid and thioester substrates. The best substrate is Boc-Ala-Ala-Nva-SBzl with a kcat/Km value of 1.0 x 10(6) M-1.s-1. We also studied the effect of C-ANCA on PR3 proteolytic activity towards elastin and inactivation by alpha 1-antitrypsin (alpha 1AT). C-ANCA IgG from 8 patients with active Wegener's granulomatosis were tested and found to inhibit elastin degradation by PR3 and to prevent the inactivation of PR3 by alpha 1AT.Entities:
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Year: 1993 PMID： 8296674 DOI： 10.1007/978-1-4757-9182-2_7
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622