| Literature DB >> 8295715 |
C H Davies1, M F Pozza, G L Collingridge.
Abstract
The new GABAB receptor antagonist CGP 55845A was tested on pre- and post-synaptic GABAB receptors in the hippocampus. CGP 55845A (1 microM) blocked (-)-baclofen (5-10 microM)-induced postsynaptic hyperpolarization and depression of evoked IPSPs and EPSPs. It also blocked three physiological consequences of GABAB receptor activation: the late IPSP, paired-pulse depression of IPSCs, and heterosynaptic depression of EPSPs. Therefore, CGP 55845A is an antagonist at pre- and post-synaptic GABAB receptors in the hippocampus and is approximately three orders of magnitude more potent than previously described GABAB receptor antagonists.Entities:
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Year: 1993 PMID： 8295715 DOI： 10.1016/0028-3908(93)90073-c
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250