Literature DB >> 8295094

Effects of sex hormones on production of prostaglandin E2 by human peripheral monocytes.

M Miyagi1, M Morishita, Y Iwamoto.   

Abstract

The effects of sex hormones on the vitro production of prostaglandin (PG) E2 by monocytes were investigated. Monocytes were obtained from heparinized peripheral blood of healthy adults and incubated for 24 hours with lipopolysaccharide (LPS) and sex hormones. After incubation, the medium was assayed for PGE2 by means of radioimmunoassay. PGE2 production by monocytes was enhanced by progesterone. Estradiol reduced PGE2 production at 0.4 ng/ml, but enhanced it at 20 ng/ml. Testosterone reduced PGE2 production. The reduced PGE2 production by monocytes treated with 0.4 ng/ml of estradiol was restored to the control level by addition of progesterone at 20 ng/ml. These results suggest that sex hormones may modulate gingival inflammation mediated by PGE2.

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Year:  1993        PMID： 8295094     DOI： 10.1902/jop.1993.64.11.1075

Source DB:  PubMed          Journal:  J Periodontol        ISSN： 0022-3492            Impact factor:   6.993


  8 in total

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3.  Pain Perception and Anxiety Levels during Menstrual Cycle Associated with Periodontal Therapy.

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Journal:  Int J Dent       Date:  2014-10-12

Review 4.  Relationship between gingival inflammation and pregnancy.

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Journal:  Mediators Inflamm       Date:  2015-03-22       Impact factor: 4.711

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6.  The influence of sex steroid hormones on gingiva of women.

Authors:  Eleni Markou; Boura Eleana; Tsalikis Lazaros; Konstantinides Antonios
Journal:  Open Dent J       Date:  2009-06-05

7.  A study to evaluate mobility of teeth during menstrual cycle using Periotest.

Authors:  Poonam Mishra; P P Marawar; Girish Byakod; Jyoti Mohitey; Sunil S Mishra
Journal:  J Indian Soc Periodontol       Date:  2013-03

Review 8.  Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung.

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  8 in total

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