Marginal periodontitis and cytokines: a review of the literature.

Recent research on the immunopathogenesis of marginal periodontitis has focused on cytokines, because these mediators govern biological activities in inflammatory tissue destruction. Several studies have been carried out to elucidate the involvement of cytokines in periodontitis, including cytokine measurements in samples from gingival tissue, gingival crevicular fluid, and in supernatants of stimulated in vitro grown cells from gingival tissue and peripheral blood. The results, summarized in this review, suggest that cytokines are involved in the progress of periodontitis. Furthermore, cytokines may be valuable as markers of tissue breakdown. At the present stage, however, there are difficulties in detecting and quantifying cytokines by immunochemical methods and, in particular, by bioassays. Increased knowledge of the cytokine network may open new pathways of periodontitis treatment by controlling processes involved in tissue breakdown.