Literature DB >> 8294512

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes.

T P McGee1, H B Skinner, E A Whitters, S A Henry, V A Bankaitis.   

Abstract

SEC14p is required for protein transport from the yeast Golgi complex. We describe a quantitative analysis of yeast bulk membrane and Golgi membrane phospholipid composition under conditions where Golgi secretory function has been uncoupled from its usual SEC14p requirement. The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.

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Year:  1994        PMID： 8294512      PMCID： PMC2119930          DOI： 10.1083/jcb.124.3.273

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  31 in total

1.  Phospholipid transfer proteins: a biological debut.

Authors:  A Cleves; T McGee; V Bankaitis
Journal:  Trends Cell Biol       Date:  1991-07       Impact factor: 20.808

2.  The effects of vanadate on the plasma membrane ATPase of Neurospora crassa.

Authors:  B J Bowman; C W Slayman
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

3.  Phospholipid transfer market.

Authors:  J E Rothman
Journal:  Nature       Date:  1990-10-11       Impact factor: 49.962

4.  SACCHAROMYCES CEREVISIAE Recessive Suppressor That Circumvents Phosphatidylserine Deficiency.

Authors:  K D Atkinson
Journal:  Genetics       Date:  1984-11       Impact factor: 4.562

5.  Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants.

Authors:  M L Greenberg; B Reiner; S A Henry
Journal:  Genetics       Date:  1982-01       Impact factor: 4.562

6.  The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex.

Authors:  V A Bankaitis; D E Malehorn; S D Emr; R Greene
Journal:  J Cell Biol       Date:  1989-04       Impact factor: 10.539

7.  Phospholipid transfer activity is relevant to but not sufficient for the essential function of the yeast SEC14 gene product.

Authors:  H B Skinner; J G Alb; E A Whitters; G M Helmkamp; V A Bankaitis
Journal:  EMBO J       Date:  1993-12       Impact factor: 11.598

8.  Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

Authors:  A Franzusoff; K Redding; J Crosby; R S Fuller; R Schekman
Journal:  J Cell Biol       Date:  1991-01       Impact factor: 10.539

9.  SEC11 is required for signal peptide processing and yeast cell growth.

Authors:  P C Böhni; R J Deshaies; R W Schekman
Journal:  J Cell Biol       Date:  1988-04       Impact factor: 10.539

10.  Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function.

Authors:  A E Cleves; P J Novick; V A Bankaitis
Journal:  J Cell Biol       Date:  1989-12       Impact factor: 10.539
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  52 in total

1.  Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.

Authors:  M P Rivas; B G Kearns; Z Xie; S Guo; M C Sekar; K Hosaka; S Kagiwada; J D York; V A Bankaitis
Journal:  Mol Biol Cell       Date:  1999-07       Impact factor: 4.138

2.  Essential role for diacylglycerol in protein transport from the yeast Golgi complex.

Authors:  B G Kearns; T P McGee; P Mayinger; A Gedvilaite; S E Phillips; S Kagiwada; V A Bankaitis
Journal:  Nature       Date:  1997-05-01       Impact factor: 49.962

3.  Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools.

Authors:  Vytas A Bankaitis; Patrick Vincent; Maria Merkulova; Kim Tyeryar; Yang Liu
Journal:  Adv Enzyme Regul       Date:  2007-03-01

Review 4.  Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae.

Authors:  George M Carman; Susan A Henry
Journal:  J Biol Chem       Date:  2007-11-02       Impact factor: 5.157

Review 5.  The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.

Authors:  Carl J Mousley; Kimberly R Tyeryar; Patrick Vincent-Pope; Vytas A Bankaitis
Journal:  Biochim Biophys Acta       Date:  2007-04-12

Review 6.  Diacylglycerol kinases in membrane trafficking.

Authors:  Shuwei Xie; Naava Naslavsky; Steve Caplan
Journal:  Cell Logist       Date:  2015-08-03

7.  Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae.

Authors:  Hyeon-Son Choi; George M Carman
Journal:  J Biol Chem       Date:  2007-08-30       Impact factor: 5.157

8.  Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae.

Authors:  T P McGee; H B Skinner; V A Bankaitis
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

9.  The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity.

Authors:  Annette L Henneberry; Marcia M Wright; Christopher R McMaster
Journal:  Mol Biol Cell       Date:  2002-09       Impact factor: 4.138

10.  Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function.

Authors:  Paramasivam Natarajan; Jiyi Wang; Zhaolin Hua; Todd R Graham
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-12       Impact factor: 11.205
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