Literature DB >> 8294235

FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.

K Sakamoto1, E Tsujii, M Miyauchi, T Nakanishi, M Yamashita, N Shigematsu, T Tada, S Izumi, M Okuhara.   

Abstract

FR901459, a novel immunosuppressant, has been isolated from the fermentation broth of Stachybotrys chartarum No. 19392. The molecular formula of FR901459 was determined as C62H111N11O13. FR901459 was found to be a member of the cyclosporin family. However, it is structurally distinct from any other cyclosporins discovered so far, in that Leu is present at position 5 instead of Val. FR901459 was capable of prolonging the survival time of skin allografts in rats with one third the potency of cyclosporin A.

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Year:  1993        PMID： 8294235     DOI： 10.7164/antibiotics.46.1788

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  13 in total

1.  [Health effects of indoor molds].

Authors:  Walter Buzina
Journal:  Wien Med Wochenschr       Date:  2007

2.  Bioconversion of FR901459, a novel derivative of cyclosporin A, by Lentzea sp. 7887.

Authors:  Satoshi Sasamura; Motoo Kobayashi; Hideyuki Muramatsu; Seiji Yoshimura; Takayoshi Kinoshita; Hidenori Ohki; Kazuki Okada; Yoko Deai; Yukiko Yamagishi; Michizane Hashimoto
Journal:  J Antibiot (Tokyo)       Date:  2015-03-18       Impact factor: 2.649

3.  Genome Features and AntiSMASH Analysis of an Endophytic Strain Fusarium sp. R1.

Authors:  Yuanyuan Liu; Meijie Xu; Yuqi Tang; Yilan Shao; Hong Wang; Huawei Zhang
Journal:  Metabolites       Date:  2022-06-04

4.  Germination, viability and clearance of Stachybotrys chartarum in the lungs of infant rats.

Authors:  Iwona Yike; Stephen Vesper; Joseph F Tomashefski; Dorr G Dearborn
Journal:  Mycopathologia       Date:  2003       Impact factor: 2.574

5.  Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum.

Authors:  Iwona Yike; Martha J Miller; W G Sorenson; Ronald Walenga; Joseph F Tomashefski; Dorr G Dearborn
Journal:  Mycopathologia       Date:  2002       Impact factor: 2.574

6.  Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants.

Authors:  B B Jarvis; W G Sorenson; E L Hintikka; M Nikulin; Y Zhou; J Jiang; S Wang; S Hinkley; R A Etzel; D Dearborn
Journal:  Appl Environ Microbiol       Date:  1998-10       Impact factor: 4.792

Review 7.  Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective.

Authors:  D M Kuhn; M A Ghannoum
Journal:  Clin Microbiol Rev       Date:  2003-01       Impact factor: 26.132

Review 8.  Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.

Authors:  D G Dearborn; I Yike; W G Sorenson; M J Miller; R A Etzel
Journal:  Environ Health Perspect       Date:  1999-06       Impact factor: 9.031

9.  The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster.

Authors:  Kathryn E Bushley; Rajani Raja; Pankaj Jaiswal; Jason S Cumbie; Mariko Nonogaki; Alexander E Boyd; C Alisha Owensby; Brian J Knaus; Justin Elser; Daniel Miller; Yanming Di; Kerry L McPhail; Joseph W Spatafora
Journal:  PLoS Genet       Date:  2013-06-20       Impact factor: 5.917

10.  Some optimal culture conditions for production of cyclosporin a by Fusarium roseum.

Authors:  Ahmed A Ismaiel; A El-Sayed; Asmaa A Mahmoud
Journal:  Braz J Microbiol       Date:  2010-12-01       Impact factor: 2.476
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