Literature DB >> 8294148

Rat ciliary neurotrophic factor (CNTF): gene structure and regulation of mRNA levels in glial cell cultures.

P Carroll1, M Sendtner, M Meyer, H Thoenen.   

Abstract

The structure of the rat ciliary neurotrophic factor (CNTF) gene and the regulation of CNTF mRNA levels in cultured glial cells were investigated. The rat mRNA is encoded by a simple two-exon transcription unit. Sequence analysis of the region upstream of the transcription start-site did not reveal a typical TATA-box consensus sequence. Low levels of CNTF mRNA were detected in cultured Schwann cells, and CNTF mRNA was not increased by a variety of treatments. Three-week-old astrocyte-enriched cell cultures from new-born rat brain contained easily detectable CNTF mRNA. In astrocyte-enriched cultures, upregulation of CNTF mRNA levels was observed after treatment with IFN-gamma. CNTF mRNA levels were down-regulated in these cells by treatments that elevate intracellular cyclic AMP and by members of the fibroblast growth factor (FGF) family. The implications of these results for potential in vivo functions of CNTF are discussed.

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Year:  1993        PMID： 8294148     DOI： 10.1002/glia.440090303

Source DB:  PubMed          Journal:  Glia        ISSN： 0894-1491            Impact factor:   7.452


  12 in total

1.  Is S-100 protein a suitable marker for adult Schwann cells?

Authors:  Z V Garavito; J J Sutachán; V C Muñetón; H Hurtado
Journal:  In Vitro Cell Dev Biol Anim       Date:  2000-05       Impact factor: 2.416

2.  Inhibition of astrocyte FAK-JNK signaling promotes subventricular zone neurogenesis through CNTF.

Authors:  Cuihong Jia; Matthew P Keasey; Chiharu Lovins; Theo Hagg
Journal:  Glia       Date:  2018-11       Impact factor: 7.452

3.  Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system.

Authors:  M T Berhow; N Hiroi; L A Kobierski; S E Hyman; E J Nestler
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

4.  Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells.

Authors:  Yasuhiro Ito; Stefan Wiese; Natalja Funk; Alexandra Chittka; Wilfried Rossoll; Heike Bömmel; Kazuhiko Watabe; Michael Wegner; Michael Sendtner
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-09       Impact factor: 11.205

5.  Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus.

Authors:  Jason M Askvig; Laura J Leiphon; John A Watt
Journal:  Exp Neurol       Date:  2011-10-19       Impact factor: 5.330

6.  P2X7 receptor inhibition increases CNTF in the subventricular zone, but not neurogenesis or neuroprotection after stroke in adult mice.

Authors:  Seong Su Kang; Matthew Phillip Keasey; Theo Hagg
Journal:  Transl Stroke Res       Date:  2013-10       Impact factor: 6.829

7.  A distinct pattern of trophic factor expression in myelin-deficient nerves of Trembler mice: implications for trophic support by Schwann cells.

Authors:  H C Friedman; T N Jelsma; G M Bray; A J Aguayo
Journal:  J Neurosci       Date:  1996-09-01       Impact factor: 6.167

8.  Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion.

Authors:  M Y Lee; T Deller; M Kirsch; M Frotscher; H D Hofmann
Journal:  J Neurosci       Date:  1997-02-01       Impact factor: 6.167

9.  Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.

Authors:  Seong Su Kang; Matthew P Keasey; Jun Cai; Theo Hagg
Journal:  J Neurosci       Date:  2012-07-04       Impact factor: 6.167

10.  Serotonin 1A receptor agonist increases species- and region-selective adult CNS proliferation, but not through CNTF.

Authors:  Sheila A Arnold; Theo Hagg
Journal:  Neuropharmacology       Date:  2012-08-05       Impact factor: 5.250
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