[Effect of injuries of the median forebrain bundle and the preoptic area on the activity of the strychnine-induced epileptiform focus (concerning the phenomenon of the hyperactive determinant transmission center)].

It was shown in experiments on cats that a lesion of the medial forebrain bundle (MFB) and partly of the preoptic region (RPO) at the side of local strychnine application of the cortex (g. suprasylvius medius) resulted in depression of the epileptiform activity in the strychnine-induced focus, as well as in the second "mirror" focus appearing in the symmetrical cortical area of the other hemisphere. This effect could also be obtained under conditions of injury of the MFB alone. The lesion of the MFB and partly of the RPO at the side of the "Mirror" focus leads to depression of the spike potentials in this focus only and does not influence the activity in the primary epileptiform focus. The described effects are considered from the aspect of conceptions of the role played by the determinant dispatch station (DDS) in the central nervous system activity: the primary epileptiform focus plays the role of the hyperactive DDS which induces the development of the secondary foci and maintaines and determines the character of their activity. The results of these studies suggest the participation of the MFB in the modulation of the epileptiform activity in the cortex.