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Literature DB >> 8293752

Mechanisms and control of repolarization.

E Carmeliet¹.
1. University of Leuven, Belgium.

Abstract

This paper describes and discusses interventions that may lead to prolongation of the action potential. Special emphasis is given to regulation by drugs. The results of studies focusing on the modulation of inward and outward currents are presented in detail. Specific attention is given to Na+, Ca2+, K+ and Cl- channel currents and their components.

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8293752 DOI： 10.1093/eurheartj/14.suppl_h.3

Source DB: PubMed Journal: Eur Heart J ISSN： 0195-668X Impact factor: 29.983

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Cited

14 in total

Review 1. Antiarrhythmics--from cell to clinic: past, present, and future.

Authors: J C Hancox; K C Patel; J V Jones
Journal: Heart Date: 2000-07 Impact factor: 5.994

2. Differences in the effects of urinary incontinence agents S-oxybutynin and terodiline on cardiac K(+) currents and action potentials.

Authors: S E Jones; L M Shuba; P Zhabyeyev; J R McCullough; T F McDonald
Journal: Br J Pharmacol Date: 2000-09 Impact factor: 8.739

3. A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes.

Authors: K Ishihara; T Ehara
Journal: J Physiol Date: 1998-08-01 Impact factor: 5.182

4. Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration.

Authors: C Lengyel; N Iost; L Virág; A Varró; D A Lathrop; J G Papp
Journal: Br J Pharmacol Date: 2001-01 Impact factor: 8.739

5. Blockade of HERG cardiac K+ current by antifungal drug miconazole.

Authors: Kan Kikuchi; Toshihisa Nagatomo; Haruhiko Abe; Kazunobu Kawakami; Henry J Duff; Jonathan C Makielski; Craig T January; Yasuhide Nakashima
Journal: Br J Pharmacol Date: 2005-03 Impact factor: 8.739

6. Electrophysiological basis for antiarrhythmic efficacy, positive inotropy and low proarrhythmic potential of (-)-caryachine.

Authors: M H Wu; M J Su; S S Lee; L T Lin; M L Young
Journal: Br J Pharmacol Date: 1995-12 Impact factor: 8.739

Mechanisms and control of repolarization.

Review 1. Antiarrhythmics--from cell to clinic: past, present, and future.

2. Differences in the effects of urinary incontinence agents S-oxybutynin and terodiline on cardiac K(+) currents and action potentials.

3. A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes.

4. Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration.

5. Blockade of HERG cardiac K+ current by antifungal drug miconazole.

6. Electrophysiological basis for antiarrhythmic efficacy, positive inotropy and low proarrhythmic potential of (-)-caryachine.

7. The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization.

8. Bertosamil blocks HERG potassium channels in their open and inactivated states.

9. Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.

10. Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle.