Literature DB >> 8292639

Diminished illicit drug use as a consequence of long-term methadone maintenance.

E Gottheil1, R C Sterling, S P Weinstein.   

Abstract

In the twenty-five years since its introduction as a treatment for opiate addiction, methadone maintenance has generated considerable controversy regarding both its appropriateness as a treatment modality and its efficacy in diminishing opiate abuse. Given current concerns regarding the spread of HIV amongst IV drug abusers, the role of methadone maintenance may be more important than ever. The present study was designed to examine continued illicit substance abuse by 229 patients enrolled in methadone treatment as a function of time in treatment (three months to over 10 years). Patients' urinalysis results collected over a 3 month period indicated that (a) cocaine use is a problem amongst methadone maintained individuals and does not appear to be related to length of time on the program, (b) cocaine use did not lead to escalated opiate and other illicit drug abuse, and (c) opiate abuse decreased significantly with time in treatment. Specifically, while 35% of the patients enrolled for less than 12 months were opiate free for the 3 month period, that value increased to 71% for patients enrolled for more than 4 years, and 85% for patients remaining in treatment for over 10 years. These results based on urinalysis support the conclusion of Ball and Ross (1991), based on ASI scores and criminality data, that methadone is an effective treatment modality for opiate addicted individuals.

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Year:  1993        PMID: 8292639     DOI: 10.1300/J069v12n04_04

Source DB:  PubMed          Journal:  J Addict Dis        ISSN: 1055-0887


  23 in total

1.  Concentrations of methadone in breast milk and plasma in the immediate perinatal period.

Authors:  Lauren M Jansson; Robin E Choo; Cheryl Harrow; Martha Velez; Jennifer R Schroeder; Ross Lowe; Marilyn A Huestis
Journal:  J Hum Lact       Date:  2007-05       Impact factor: 2.219

2.  Enhancement of cocaine's abuse liability in methadone maintenance patients.

Authors:  K L Preston; J T Sullivan; E C Strain; G E Bigelow
Journal:  Psychopharmacology (Berl)       Date:  1996-01       Impact factor: 4.530

3.  Methadone treatment for opiate addicts.

Authors:  J L Sorensen
Journal:  BMJ       Date:  1996-08-03

4.  Initiation and Rapid Titration of Methadone in an Acute Care Setting for the Treatment of Opioid Use Disorder: A Case Report.

Authors:  Patrick Hemmons; Paxton Bach; Kate Colizza; Seonaid Nolan
Journal:  J Addict Med       Date:  2019 Sep/Oct       Impact factor: 3.702

5.  Prediction of stress and drug craving ninety minutes in the future with passively collected GPS data.

Authors:  David H Epstein; Matthew Tyburski; William J Kowalczyk; Albert J Burgess-Hull; Karran A Phillips; Brenda L Curtis; Kenzie L Preston
Journal:  NPJ Digit Med       Date:  2020-03-04

Review 6.  Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal.

Authors:  J L Scavone; R C Sterling; E J Van Bockstaele
Journal:  Neuroscience       Date:  2013-04-24       Impact factor: 3.590

7.  A randomized trial of methadone initiation prior to release from incarceration.

Authors:  Michelle McKenzie; Nickolas Zaller; Samuel L Dickman; Traci C Green; Amisha Parihk; Peter D Friedmann; Josiah D Rich
Journal:  Subst Abus       Date:  2012       Impact factor: 3.716

8.  Psychological and physiological stress negatively impacts early engagement and retention of opioid-dependent individuals on methadone maintenance.

Authors:  Kellie M Jaremko; Robert C Sterling; Elisabeth J Van Bockstaele
Journal:  J Subst Abuse Treat       Date:  2014-08-29

9.  Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study.

Authors:  George H Trksak; J Eric Jensen; David T Plante; David M Penetar; Wendy L Tartarini; Melissa A Maywalt; Michael Brendel; Cynthia M Dorsey; Perry F Renshaw; Scott E Lukas
Journal:  Drug Alcohol Depend       Date:  2009-09-22       Impact factor: 4.492

10.  Prenatal methadone exposure and neonatal neurobehavioral functioning.

Authors:  Martha L Velez; Lauren M Jansson; Jennifer Schroeder; Erica Williams
Journal:  Pediatr Res       Date:  2009-12       Impact factor: 3.756

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