| Literature DB >> 8292560 |
E P Das-Gupta1, T J Lyons, J A Hoyland, D M Lawton, A J Freemont.
Abstract
Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These include the presence of a prominent acute and chronic synovial inflammatory infiltrate. Such findings call into question the proposed aetiology of the arthropathy in this strain of mouse and its acceptability as a model of human primary OA.Entities:
Mesh：
Year: 1993 PMID： 8292560 PMCID： PMC2002252
Source DB: PubMed Journal: Int J Exp Pathol ISSN： 0959-9673 Impact factor: 1.925