Literature DB >> 8292043

Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid.

M Floer1, J Stock.   

Abstract

Protein phosphatase 2A is the principal carboxyl methylated protein in cytoplasmic extracts derived from Xenopus eggs arrested in interphase. Levels of methylation approach stoichiometric values after 2 hr of incubation at 22 degrees C. Rates of PP2A methylation increase by over 50% upon addition of cAMP. Methylation is inhibited by okadaic acid at concentrations that inhibit PP2A phosphatase activity.

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Year:  1994        PMID： 8292043     DOI： 10.1006/bbrc.1994.1052

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits.

Authors:  T Tolstykh; J Lee; S Vafai; J B Stock
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen.

Authors:  X X Yu; X Du; C S Moreno; R E Green; E Ogris; Q Feng; L Chou; M J McQuoid; D C Pallas
Journal:  Mol Biol Cell       Date:  2001-01       Impact factor: 4.138

Review 3.  The role of serine/threonine protein phosphatases in exocytosis.

Authors:  Alistair T R Sim; Monique L Baldwin; John A P Rostas; Jeff Holst; Russell I Ludowyke
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

4.  Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

Authors:  Jocelyn A Lee; Zhengqi Wang; Danielle Sambo; Kevin D Bunting; David C Pallas
Journal:  J Biol Chem       Date:  2018-05-07       Impact factor: 5.157

5.  Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation.

Authors:  Tineke Lauwaet; Barbara J Davids; Ascención Torres-Escobar; Shanda R Birkeland; Michael J Cipriano; Sarah P Preheim; Daniel Palm; Staffan G Svärd; Andrew G McArthur; Frances D Gillin
Journal:  Mol Biochem Parasitol       Date:  2006-12-22       Impact factor: 1.759

6.  A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.

Authors:  Kyoungja Hong; Liguang Lou; Sandhya Gupta; Fernando Ribeiro-Neto; Daniel L Altschuler
Journal:  J Biol Chem       Date:  2008-06-12       Impact factor: 5.157

7.  A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain.

Authors:  J Lee; Y Chen; T Tolstykh; J Stock
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

Review 8.  Serine/threonine protein phosphatases.

Authors:  S Wera; B A Hemmings
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

9.  The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.

Authors:  Suiyang Li; Claudine Brignole; Richard Marcellus; Sara Thirlwell; Olivier Binda; Monica J McQuoid; Danita Ashby; Helen Chan; Zhiying Zhang; Marie-Joëlle Miron; David C Pallas; Philip E Branton
Journal:  J Virol       Date:  2009-06-17       Impact factor: 5.103

10.  A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.

Authors:  E Ogris; X Du; K C Nelson; E K Mak; X X Yu; W S Lane; D C Pallas
Journal:  J Biol Chem       Date:  1999-05-14       Impact factor: 5.157
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