Literature DB >> 8291571

Male siblings with schizophrenia share alleles at the androgen receptor above chance expectation.

T J Crow1, M Poulter, R Lofthouse, G Chen, T Shah, N Bass, C Morganti, A Vita, C Smith, A Boccio-Smith.   

Abstract

In families that included two or more siblings with schizophrenia or schizo-affective disorder male-male pairs were found to share alleles at the androgen receptor (AR) gene (in Xq11.2-q12) above chance expectation (p < 0.003); female-female and mixed sex pairs showed no such tendency. The findings are compatible with X-Y linkage or with an X-linked contribution to liability in males.

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Year:  1993        PMID: 8291571     DOI: 10.1002/ajmg.1320480309

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN: 0148-7299


  4 in total

1.  The Sex Chromosome Hypothesis of Schizophrenia: Alive, Dead, or Forgotten? A Commentary and Review.

Authors:  William K Bache; Lynn E DeLisi
Journal:  Mol Neuropsychiatry       Date:  2018-08-20

2.  Corpus callosal area differences and gender dimorphism in neuroleptic-naïve, recent-onset schizophrenia and healthy control subjects.

Authors:  John P John; Mohammed Kalathil Shakeel; Sanjeev Jain
Journal:  Schizophr Res       Date:  2008-06-26       Impact factor: 4.939

3.  Variants of the RELA gene are associated with schizophrenia and their startle responses.

Authors:  Ryota Hashimoto; Kazutaka Ohi; Yuka Yasuda; Motoyuki Fukumoto; Hidenaga Yamamori; Hidetoshi Takahashi; Masao Iwase; Tomo Okochi; Hiroaki Kazui; Osamu Saitoh; Masahiko Tatsumi; Nakao Iwata; Norio Ozaki; Kunitoshi Kamijima; Hiroshi Kunugi; Masatoshi Takeda
Journal:  Neuropsychopharmacology       Date:  2011-05-18       Impact factor: 7.853

Review 4.  Dopamine-prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity.

Authors:  C Gragnoli; G M Reeves; J Reazer; T T Postolache
Journal:  Transl Psychiatry       Date:  2016-04-19       Impact factor: 6.222

  4 in total

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