Literature DB >> 8291223

Paraneoplastic intestinal pseudo-obstruction associated with high titres of Hu autoantibodies.

E Condom1, A Vidal, R Rota, F Graus, J Dalmau, I Ferrer.   

Abstract

Anti-Hu autoantibodies in high titres, as revealed with immunocytochemistry and Western blot, were present in a patient with gastrointestinal pseudo-obstruction and small-cell lung cancer (SCLC) bearing the Hu antigen. Marked neuron and nerve fibre loss were found in the myenteric plexus at postmortem. These findings show that neuronopathic Hu-associated gastrointestinal pseudo-obstruction can occur as the only paraneoplastic neurological symptom in patients with SCLC.

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Year:  1993        PMID： 8291223     DOI： 10.1007/BF01606543

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  14 in total

1.  Anti-Hu--associated paraneoplastic encephalomyelitis/sensory neuronopathy. A clinical study of 71 patients.

Authors:  J Dalmau; F Graus; M K Rosenblum; J B Posner
Journal:  Medicine (Baltimore)       Date:  1992-03       Impact factor: 1.889

2.  Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract.

Authors:  M D Schuffler; H W Baird; C R Fleming; C E Bell; T W Bouldin; J R Malagelada; D B McGill; S M LeBauer; M Abrams; J Love
Journal:  Ann Intern Med       Date:  1983-02       Impact factor: 25.391

3.  Neuronal antinuclear antibody in sensory neuronopathy from lung cancer.

Authors:  F Graus; C Cordon-Cardo; J B Posner
Journal:  Neurology       Date:  1985-04       Impact factor: 9.910

4.  Paraneoplastic visceral neuropathy as a cause of severe gastrointestinal motor dysfunction.

Authors:  J S Chinn; M D Schuffler
Journal:  Gastroenterology       Date:  1988-11       Impact factor: 22.682

5.  Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer--a quantitative western blot analysis.

Authors:  J Dalmau; H M Furneaux; R J Gralla; M G Kris; J B Posner
Journal:  Ann Neurol       Date:  1990-05       Impact factor: 10.422

6.  Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma.

Authors:  V A Lennon; D F Sas; M F Busk; B Scheithauer; J R Malagelada; M Camilleri; L J Miller
Journal:  Gastroenterology       Date:  1991-01       Impact factor: 22.682

7.  Paraneoplastic anti-Purkinje and type I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells.

Authors:  H J Altermatt; M Rodriguez; B W Scheithauer; V A Lennon
Journal:  Lab Invest       Date:  1991-10       Impact factor: 5.662

8.  Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies.

Authors:  R B Darnell; L M DeAngelis
Journal:  Lancet       Date:  1993-01-02       Impact factor: 79.321

9.  [Paralysis of digestive tract with lesions of myenteric plexuses. A new paraneoplastic syndrome (author's transl)].

Authors:  F Lhermitte; F Gray; O Lyon-Caen; B F Pertuiset; P Bernard
Journal:  Rev Neurol (Paris)       Date:  1980       Impact factor: 2.607

10.  The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues.

Authors:  J Dalmau; H M Furneaux; C Cordon-Cardo; J B Posner
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307
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  4 in total

1.  DPPX antibody-associated encephalitis: Main syndrome and antibody effects.

Authors:  Makoto Hara; Helena Ariño; Mar Petit-Pedrol; Lidia Sabater; Maarten J Titulaer; Eugenia Martinez-Hernandez; Marco W J Schreurs; Myrna R Rosenfeld; Francesc Graus; Josep Dalmau
Journal:  Neurology       Date:  2017-03-03       Impact factor: 9.910

2.  Pseudoachalasia of the cardia secondary to nongastrointestinal neoplasia.

Authors:  Jose Luis Ulla; Estela Fernandez-Salgado; Victoria Alvarez; Alberto Ibañez; Santiago Soto; Daniel Carpio; Javier Vazquez-Sanluis; Luis Ledo; Enrique Vazquez-Astray
Journal:  Dysphagia       Date:  2007-08-15       Impact factor: 3.438

3.  Integrated treatment for autonomic paraneoplastic syndrome improves performance status in a patient with small lung cell carcinoma: a case report.

Authors:  Tatsuya Ueno; Yukihiro Hasegawa; Rie Hagiwara; Tomoya Kon; Jin-Ichi Nunomura; Masahiko Tomiyama
Journal:  BMC Neurol       Date:  2018-11-10       Impact factor: 2.474

Review 4.  Tumor-related dysmotility: gastrointestinal dysmotility syndromes associated with tumors.

Authors:  J K DiBaise; E M Quigley
Journal:  Dig Dis Sci       Date:  1998-07       Impact factor: 3.487
  4 in total

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