Literature DB >> 8290054

A case of Down's syndrome with diffuse Lewy body disease and Alzheimer's disease.

S Bodhireddy1, D W Dickson, L Mattiace, K M Weidenheim.   

Abstract

Almost all Down's syndrome (DS) patients over the age of 35 to 40 years have histologic features of Alzheimer's disease (AD). However, the presence of extrapyramidal features in up to 36% of these patients has no satisfactory pathologic explanation. We report an older patient with DS, dementia, and parkinsonian signs who showed pathologic changes of Parkinson's disease and cortical Lewy bodies in addition to AD. These parkinsonian changes may be related to chromosome 21 abnormalities.

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Year:  1994        PMID： 8290054     DOI： 10.1212/wnl.44.1.159

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  4 in total

1.  Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia.

Authors:  L A Hansen; S E Daniel; G K Wilcock; S Love
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-05       Impact factor: 10.154

2.  Down's syndrome and Parkinson's disease.

Authors:  A Hestnes; S E Daniel; A J Lees; A Brun
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-03       Impact factor: 10.154

Review 3.  Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches.

Authors:  Clíona Farrell; Paige Mumford; Frances K Wiseman
Journal:  Front Neurosci       Date:  2022-06-07       Impact factor: 5.152

4.  Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.

Authors:  C F Lippa; H Fujiwara; D M Mann; B Giasson; M Baba; M L Schmidt; L E Nee; B O'Connell; D A Pollen; P St George-Hyslop; B Ghetti; D Nochlin; T D Bird; N J Cairns; V M Lee; T Iwatsubo; J Q Trojanowski
Journal:  Am J Pathol       Date:  1998-11       Impact factor: 4.307
  4 in total

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