Literature DB >> 8289995

Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation follow-up.

L Le Moyec1, A Pruna, M Eugène, J Bedrossian, J M Idatte, J F Huneau, D Tomé.   

Abstract

Urine and plasma samples from 39 patients who underwent renal transplantation were analyzed by proton nuclear magnetic resonance (NMR) spectroscopy. The most relevant resonances for evaluating renal function after transplantation were those arising from citrate, trimethylamine-N-oxide (TMAO), alanine, and lactate when compared to creatinine. A resonance at 3.7 ppm was related to cyclosporine toxicity when associated with elevated levels of TMAO. The respective variations in these metabolites in urine could contribute to prognosis and diagnosis of renal function impairment related to cyclosporine toxicity or overdosage, or to rejection. Thus, NMR spectroscopy should improve the follow-up and management of renal transplantation patients.

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Year:  1993        PMID： 8289995     DOI： 10.1159/000187525

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   2.847


  12 in total

Review 1.  Analytical approaches to metabolomics and applications to systems biology.

Authors:  Jeffrey H Wang; Jaeman Byun; Subramaniam Pennathur
Journal:  Semin Nephrol       Date:  2010-09       Impact factor: 5.299

2.  Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose.

Authors:  Jost Klawitter; Manuel Haschke; Christine Kahle; Colleen Dingmann; Jelena Klawitter; Dieter Leibfritz; Uwe Christians
Journal:  Br J Clin Pharmacol       Date:  2010-08       Impact factor: 4.335

3.  Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease.

Authors:  W H Wilson Tang; Zeneng Wang; David J Kennedy; Yuping Wu; Jennifer A Buffa; Brendan Agatisa-Boyle; Xinmin S Li; Bruce S Levison; Stanley L Hazen
Journal:  Circ Res       Date:  2014-11-05       Impact factor: 17.367

Review 4.  Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions.

Authors:  Uwe Christians; Jost Klawitter; Jelena Klawitter; Nina Brunner; Volker Schmitz
Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-02       Impact factor: 4.481

5.  A pilot metabolic profiling study in serum of patients with chronic kidney disease based on (1) H-NMR-spectroscopy.

Authors:  Suwen Qi; Xin Ouyang; Linqian Wang; Wujian Peng; Jinli Wen; Yong Dai
Journal:  Clin Transl Sci       Date:  2012-08-07       Impact factor: 4.689

Review 6.  Microbiome, trimethylamine N-oxide, and cardiometabolic disease.

Authors:  W H Wilson Tang; Stanley L Hazen
Journal:  Transl Res       Date:  2016-07-18       Impact factor: 7.012

Review 7.  Proteomics and metabolomics in renal transplantation-quo vadis?

Authors:  Rahul Bohra; Jacek Klepacki; Jelena Klawitter; Jost Klawitter; Joshua M Thurman; Uwe Christians
Journal:  Transpl Int       Date:  2012-11-21       Impact factor: 3.782

8.  Analysis of fetal and neonatal urine using proton nuclear magnetic resonance spectroscopy.

Authors:  P J Foxall; S Bewley; G H Neild; C H Rodeck; J K Nicholson
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  1995-11       Impact factor: 5.747

9.  Biomarkers of acute kidney injury.

Authors:  Jeffrey C Sirota; Jelena Klawitter; Charles L Edelstein
Journal:  J Toxicol       Date:  2011-10-29

Review 10.  Diagnostic Applications of Nuclear Magnetic Resonance-Based Urinary Metabolomics.

Authors:  Ana Capati; Omkar B Ijare; Tedros Bezabeh
Journal:  Magn Reson Insights       Date:  2017-03-07
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