Literature DB >> 8289690

The origin of HIV-1, the AIDS virus.

D Siefkes.   

Abstract

This article proposes a series of experiments to determine if cows and sheep could be used as animal models for HIV-1, the AIDS virus. To justify this effort, a substantial case is presented that HIV-1 is a natural recombinant of Bovine Leukemia Virus (BLV) and Visna Virus. This natural recombinant may have been inadvertently transferred to humans through the Intensified Smallpox Eradication Program conducted in sub-Saharan Africa in the late 1960s and most of the 1970s.

Entities:  

Keywords:  Acquired Immunodeficiency Syndrome; Diseases; Economic Factors; Hiv Infections; Research And Development; Technology; Theoretical Studies; Vaccines; Viral Diseases; World

Mesh：

Substances：

Year:  1993        PMID： 8289690      PMCID： PMC7173098          DOI： 10.1016/0306-9877(93)90069-3

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  74 in total

Review 1.  Evolution of RNA viruses.

Authors:  J H Strauss; E G Strauss
Journal:  Annu Rev Microbiol       Date:  1988       Impact factor: 15.500

2.  AIDS in Africa: an epidemiologic paradigm.

Authors:  T C Quinn; J M Mann; J W Curran; P Piot
Journal:  Science       Date:  1986-11-21       Impact factor: 47.728

3.  Infectivity of bovine C- type (leukemia) virus for sheep and goats.

Authors:  H E Hoss; C Olson
Journal:  Am J Vet Res       Date:  1974-05       Impact factor: 1.156

4.  A five-year serological study of natural transmission of maedi-visna virus in a flock of sheep, completed with post mortem investigation.

Authors:  D J Houwers; E J van der Molen
Journal:  Zentralbl Veterinarmed B       Date:  1987-08

5.  An ELISA for the diagnosis of bovine leukaemia virus infection.

Authors:  G Florent
Journal:  Vet Rec       Date:  1988-11-26       Impact factor: 2.695

Review 6.  AIDS: animal retrovirus models and vaccines.

Authors:  R Kurth; G Kraus; A Werner; S Hartung; P Centner; M Baier; S Norley; J Löwer
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1988

7.  HLA antibodies detected by ELISA HTLV-III antibody kits.

Authors:  J B Hunter; J E Menitove
Journal:  Lancet       Date:  1985-08-17       Impact factor: 79.321

Review 8.  Vaccination: its birth, death and resurrection. Eighth Burnet lecture of the Australian Academy of Science, 1985.

Authors:  F Fenner
Journal:  Aust J Exp Biol Med Sci       Date:  1985-12

9.  General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.

Authors:  M Mackett; G L Smith; B Moss
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

10.  Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome.

Authors:  H Kulaga; T Folks; R Rutledge; M E Truckenmiller; E Gugel; T J Kindt
Journal:  J Exp Med       Date:  1989-01-01       Impact factor: 14.307
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