Literature DB >> 8287326

Interleukin-11 inhibits bone formation in vitro.

F J Hughes1, G L Howells.   

Abstract

The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500 U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.

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Year:  1993        PMID： 8287326     DOI： 10.1007/BF01351844

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  13 in total

1.  Interleukin-6: an osteotropic factor?

Authors:  G D Roodman
Journal:  J Bone Miner Res       Date:  1992-05       Impact factor: 6.741

2.  Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.

Authors:  G L Wong; D V Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

3.  Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations.

Authors:  C G Bellows; J E Aubin; J N Heersche; M E Antosz
Journal:  Calcif Tissue Int       Date:  1986-03       Impact factor: 4.333

4.  Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats.

Authors:  C Maniatopoulos; J Sodek; A H Melcher
Journal:  Cell Tissue Res       Date:  1988-11       Impact factor: 5.249

5.  Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

Authors:  H Baumann; P Schendel
Journal:  J Biol Chem       Date:  1991-10-25       Impact factor: 5.157

6.  Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

Authors:  S R Paul; F Bennett; J A Calvetti; K Kelleher; C R Wood; R M O'Hara; A C Leary; B Sibley; S C Clark; D A Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Determination of numbers of osteoprogenitors present in isolated fetal rat calvaria cells in vitro.

Authors:  C G Bellows; J E Aubin
Journal:  Dev Biol       Date:  1989-05       Impact factor: 3.582

8.  Interleukin-6 inhibits bone formation in vitro.

Authors:  F J Hughes; G L Howells
Journal:  Bone Miner       Date:  1993-04

9.  Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.

Authors:  J M Zarling; M Shoyab; H Marquardt; M B Hanson; M N Lioubin; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

10.  Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

Authors:  M Musashi; Y C Yang; S R Paul; S C Clark; T Sudo; M Ogawa
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205
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Authors:  H Taki; E Sugiyama; T Mino; A Kuroda; M Kobayashi
Journal:  Clin Exp Immunol       Date:  1998-04       Impact factor: 4.330

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Authors:  Vishnu C Ramani; Yang Yang; Yongsheng Ren; Li Nan; Ralph D Sanderson
Journal:  J Biol Chem       Date:  2010-12-03       Impact factor: 5.157

6.  Two differentially expressed interleukin-11 receptor genes in the mouse genome.

Authors:  P Bilinski; M A Hall; H Neuhaus; C Gissel; J K Heath; A Gossler
Journal:  Biochem J       Date:  1996-12-01       Impact factor: 3.857

7.  IL1-beta and TNF-alpha induce changes in the nuclear polyphosphoinositide signalling system in osteoblasts similar to that occurring in patients with rheumatoid arthritis: an immunochemical and immunocytochemical study.

Authors:  Nicoletta Zini; Gina Lisignoli; Liliana Solimando; Alberto Bavelloni; Francesco Grassi; Lia Guidotti; Carmela Trimarchi; Andrea Facchini; Nadir Mario Maraldi
Journal:  Histochem Cell Biol       Date:  2003-08-12       Impact factor: 4.304

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Authors:  Domenica Giannandrea; Valentina Citro; Elena Lesma; Monica Bignotto; Natalia Platonova; Raffaella Chiaramonte
Journal:  Front Oncol       Date:  2021-03-22       Impact factor: 6.244

9.  IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells.

Authors:  Erin M McCoy; Huixian Hong; Hawley C Pruitt; Xu Feng
Journal:  BMC Cancer       Date:  2013-01-11       Impact factor: 4.430

Review 10.  Cellular and Molecular Mediators of Bone Metastatic Lesions.

Authors:  Giulia Battafarano; Michela Rossi; Francesco Marampon; Andrea Del Fattore
Journal:  Int J Mol Sci       Date:  2018-06-08       Impact factor: 5.923
  10 in total

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