Literature DB >> 828262

Toxicological studies on gemfibrozil.

S M Kurtz, J E Fitzgerald, R A Fisken, J L Schardein, T H Reutner, J A Lucas.   

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Year:  1976        PMID： 828262      PMCID： PMC1864019     

Source DB:  PubMed          Journal:  Proc R Soc Med        ISSN： 0035-9157


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  4 in total

1.  EXPERIMENTAL STUDIES OF THE TOXICITY OF ATROMID WITH PARTICULAR REFERENCE TO FINE STRUCTURAL CHANGES IN THE LIVERS OF RODENTS.

Authors:  G E PAGET
Journal:  J Atheroscler Res       Date:  1963 Sep-Dec

2.  Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.

Authors:  D S Platt; B L Cockrill
Journal:  Biochem Pharmacol       Date:  1967-12       Impact factor: 5.858

3.  Changes in the weight and composition of the liver in the rat, dog and monkey treated with ethyl chlorophenoxyisobutyrate.

Authors:  D S Platt; J M Thorp
Journal:  Biochem Pharmacol       Date:  1966-07       Impact factor: 5.858

4.  The bursa pharyngea in the giant panda (Ailuropoda melanoleuca).

Authors:  A J Cave
Journal:  Nature       Date:  1965-11-27       Impact factor: 49.962
  4 in total
  6 in total

1.  The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice.

Authors:  Akshata Almad; A Todd Lash; Ping Wei; Amy E Lovett-Racke; Dana M McTigue
Journal:  Exp Neurol       Date:  2011-09-21       Impact factor: 5.330

2.  Gemfibrozil pretreatment affecting antioxidant defense system and inflammatory, but not Nrf-2 signaling pathways resulted in female neuroprotection and male neurotoxicity in the rat models of global cerebral ischemia-reperfusion.

Authors:  Fatemeh Mohagheghi; Leila Khalaj; Abolhassan Ahmadiani; Behrouz Rahmani
Journal:  Neurotox Res       Date:  2012-07-07       Impact factor: 3.911

Review 3.  Gemfibrozil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in dyslipidaemia.

Authors:  P A Todd; A Ward
Journal:  Drugs       Date:  1988-09       Impact factor: 9.546

4.  Gemfibrozil pretreatment resulted in a sexually dimorphic outcome in the rat models of global cerebral ischemia-reperfusion via modulation of mitochondrial pro-survival and apoptotic cell death factors as well as MAPKs.

Authors:  Fatemeh Mohagheghi; Abolhassan Ahmadiani; Behrouz Rahmani; Fatemeh Moradi; Nathalie Romond; Leila Khalaj
Journal:  J Mol Neurosci       Date:  2013-01-05       Impact factor: 3.444

5.  Increased survival after gemfibrozil treatment of severe mouse influenza.

Authors:  Alison Budd; Lisa Alleva; Mohammed Alsharifi; Aulikki Koskinen; Victoria Smythe; Arno Müllbacher; Jeff Wood; Ian Clark
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

6.  Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties.

Authors:  Aiming Liu; Shuilin Xie; He Sun; Frank J Gonzalez; Xiaoxiong Wei; Renke Dai
Journal:  Toxicol Appl Pharmacol       Date:  2008-12-25       Impact factor: 4.219
  6 in total

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