Recurrent t(12;19)(q13;q13.3) in intracranial and extracranial hemangiopericytoma.

We report on a recurrent intracranial hemangiopericytoma cytogenetically studied after short-term culture. The tumor had a uniform karyotype 47,XX,add(7)(q21),t(12;19)(q13;q13.3),del(13)(q14q22), +21. Remarkably, one case with an identical reciprocal (12;19) translocation has been previously reported as the sole cytogenetic change in a recurrent retroperitoneal hemangiopericytoma. This nonrandom structural change may characterize a subentity of hemangiopericytoma and might be of diagnostic value.