| Literature DB >> 8280812 |
T Motyl1, M Kasterka, K Grzelkowska, S Blachowski, P Sysa.
Abstract
The present study proved that TGF-beta 1 significantly inhibited the growth of K 562 cells. The drop in cell numbers after 24 h incubation with increasing concentrations of TGF-beta 1 (0.01, 0.1, 1.0, 10.0 ng/ml) was accompanied by significant suppression of the activity of two key enzymes of polyamine biosynthesis: ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC). In contrast to ODC and SAMDC activity, TGF-beta 1 did not significantly affect the absolute concentration of spermidine and spermine in K 562 cells. We suppose that the lack of an evident drop in concentration of spermidine and spermine in spite of a significant decrease in ODC and SAMDC activity in K 562 cells exposed to TGF-beta 1 resulted from the uptake of polyamines from the extracellular space.Entities:
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Year: 1993 PMID： 8280812 DOI： 10.1007/BF01696348
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673