Literature DB >> 8280723

Antioxidative state of the myocardium and kidneys in acute diabetic rats.

K Volkovová1, V Chorváthová, M Jurcovicová, L Koszeghyová, P Bobek.   

Abstract

The influence of acute diabetes (8 days), induced by streptozotocin (45 mg.kg-1 body weight) on myocardial and renal antioxidative conditions was investigated. The animals were given subtherapeutical doses of insulin (Interdep 6 U. kg-1 body weight, s.c.). Considerably increased levels of malondialdehyde (MDA), as well as of superoxide dismutase (SOD) and catalase (CAT) activity were found in the myocardium of diabetic animals. The oxidized glutathione (GSSG) level and glutathione peroxidase (GSH-PX) activity remained unchanged. The reduced glutathione (GSH) level as well as the activity of glutathione S-transferase (GST) were significantly lower. The activity of GSH-PX in the kidneys of diabetic rats increased by 60% and that of GST by 105%, respectively. CAT and SOD activity values were unchanged.

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Year:  1993        PMID： 8280723

Source DB:  PubMed          Journal:  Physiol Res        ISSN： 0862-8408            Impact factor:   1.881


  6 in total

1.  Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats.

Authors:  D H Mak; S P Ip; P C Li; M K Poon; K M Ko
Journal:  Mol Cell Biochem       Date:  1996-09-20       Impact factor: 3.396

2.  Short-term gemfibrozil treatment reverses lipid profile and peroxidation but does not alter blood glucose and tissue antioxidant enzymes in chronically diabetic rats.

Authors:  G Ozansoy; B Akin; F Aktan; C Karasu
Journal:  Mol Cell Biochem       Date:  2001-01       Impact factor: 3.396

3.  Effect of inhibition of glutathione synthesis on insulin action: in vivo and in vitro studies using buthionine sulfoximine.

Authors:  M Khamaisi; O Kavel; M Rosenstock; M Porat; M Yuli; N Kaiser; A Rudich
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

4.  Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E.

Authors:  Nuray N Ulusu; Meral Sahilli; Aslihan Avci; Orhan Canbolat; Gülgün Ozansoy; Nuray Ari; Musa Bali; Milan Stefek; Svorad Stolc; Andrej Gajdosik; Cimen Karasu
Journal:  Neurochem Res       Date:  2003-06       Impact factor: 3.996

5.  Diabetes-induced changes in glucose synthesis, intracellular glutathione status and hydroxyl free radical generation in rabbit kidney-cortex tubules.

Authors:  K Winiarska; J Drozak; M Wegrzynowicz; T Fraczyk; J Bryla
Journal:  Mol Cell Biochem       Date:  2004-06       Impact factor: 3.396

6.  Comparison of oxidant/antioxidant, detoxification systems in various tissue homogenates and mitochondria of rats with diabetes induced by streptozocin.

Authors:  Veysel Kenan Çelık; Zeynep Deniz Şahın; İsmail Sari; Sevtap Bakir
Journal:  Exp Diabetes Res       Date:  2012-03-28
  6 in total

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