| Literature DB >> 8277311 |
J A Beutler1, J H Cardellina, G N Gray, T R Prather, R H Shoemaker, M R Boyd, C M Lin, E Hamel, G M Cragg.
Abstract
The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.Entities:
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Year: 1993 PMID： 8277311 DOI： 10.1021/np50100a009
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050