| Literature DB >> 8277249 |
J P Himanen1, L Pyhälä, R M Olander, O Merimskaya, T Kuzina, O Lysyuk, A Pronin, A Sanin, I M Helander, M Sarvas.
Abstract
To evaluate the suitability of Bacillus subtilis as a production host of heterologous proteins for pharmaceutical purposes, we assessed the biological activity of this bacterium and its major cell envelope components, lipoteichoic acid (LTA) and peptidoglycan-teichoic acid complex (PG-TA) in several eukaryotic effector assays. LTA and PG-TA were found to be non-toxic for mice and guinea-pigs in a short-term toxicity assay. PG-TA was weakly pyrogenic and weakly mitogenic. Both LTA and PG-TA acted as immunologic adjuvants in mice and when injected in mice, also caused an increase in the number of granulocyte-monocyte colony-forming cells in the bone marrow probably via stimulation of production of granulocyte-macrophage colony-stimulating factor.Entities:
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Year: 1993 PMID： 8277249 DOI： 10.1099/00221287-139-11-2659
Source DB: PubMed Journal: J Gen Microbiol ISSN： 0022-1287