Literature DB >> 8276261

The molecular and genetic dissection of the retinoid signalling pathway.

P Chambon1.   

Abstract

Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.

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Year:  1993        PMID： 8276261     DOI： 10.1016/0378-1119(93)90069-f

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

1.  RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes.

Authors:  Zhixing Wang; Daniel J Coleman; Gaurav Bajaj; Xiaobo Liang; Gitali Ganguli-Indra; Arup K Indra
Journal:  J Invest Dermatol       Date:  2010-10-14       Impact factor: 8.551

2.  Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.

Authors:  Janice Y Ahn; Jeannie T Lee
Journal:  BMC Dev Biol       Date:  2010-08-20       Impact factor: 1.978

3.  Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.

Authors:  S Carrera; S Cuadrado-Castano; J Samuel; G D D Jones; E Villar; S W Lee; S Macip
Journal:  Cell Death Differ       Date:  2013-03-01       Impact factor: 15.828

4.  Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking.

Authors:  Matthieu Schapira; Bruce M Raaka; Sharmistha Das; Li Fan; Maxim Totrov; Zhiguo Zhou; Stephen R Wilson; Ruben Abagyan; Herbert H Samuels
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-30       Impact factor: 11.205

5.  ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.

Authors:  Xingguang Luo; Henry R Kranzler; Lingjun Zuo; Huiping Zhang; Shuang Wang; Joel Gelernter
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-03-05       Impact factor: 3.568

6.  Heroin addiction in African Americans: a hypothesis-driven association study.

Authors:  O Levran; D Londono; K O'Hara; M Randesi; J Rotrosen; P Casadonte; S Linzy; J Ott; M Adelson; M J Kreek
Journal:  Genes Brain Behav       Date:  2009-06-20       Impact factor: 3.449

7.  A novel type of retinoic acid response element in the second intron of the mouse H2Kb gene is activated by the RAR/RXR heterodimer.

Authors:  P Jansa; J Forejt
Journal:  Nucleic Acids Res       Date:  1996-02-15       Impact factor: 16.971

8.  Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.

Authors:  Katri M Makkonen; Sanna Pasonen-Seppänen; Kari Törrönen; Markku I Tammi; Carsten Carlberg
Journal:  J Biol Chem       Date:  2009-05-05       Impact factor: 5.157

9.  The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

Authors:  C Zechel; X Q Shen; J Y Chen; Z P Chen; P Chambon; H Gronemeyer
Journal:  EMBO J       Date:  1994-03-15       Impact factor: 11.598

10.  Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

Authors:  C Zechel; X Q Shen; P Chambon; H Gronemeyer
Journal:  EMBO J       Date:  1994-03-15       Impact factor: 11.598
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