Literature DB >> 8276070

Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.

S Izenwasser1, A H Newman, J L Katz.   

Abstract

Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.

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Year:  1993        PMID： 8276070     DOI： 10.1016/0014-2999(93)90381-q

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.

Authors:  Seshulatha Jamalapuram; Pradeep K Vuppala; Christophe Mesangeau; Christopher R McCurdy; Bonnie A Avery
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2011-12-20       Impact factor: 3.205

Review 2.  The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.

Authors:  Danielle O Sambo; Joseph J Lebowitz; Habibeh Khoshbouei
Journal:  Pharmacol Ther       Date:  2018-01-31       Impact factor: 12.310

3.  Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.

Authors:  Takato Hiranita; Paul L Soto; Stephen J Kohut; Theresa Kopajtic; Jianjing Cao; Amy H Newman; Gianluigi Tanda; Jonathan L Katz
Journal:  J Pharmacol Exp Ther       Date:  2011-08-22       Impact factor: 4.030

4.  A behavioral economic analysis of the effects of rimcazole on reinforcing effects of cocaine injection and food presentation in rats.

Authors:  Martin O Job; Jonathan L Katz
Journal:  Psychopharmacology (Berl)       Date:  2019-08-09       Impact factor: 4.530

Review 5.  Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.

Authors:  Maarten E A Reith; Bruce E Blough; Weimin C Hong; Kymry T Jones; Kyle C Schmitt; Michael H Baumann; John S Partilla; Richard B Rothman; Jonathan L Katz
Journal:  Drug Alcohol Depend       Date:  2014-12-18       Impact factor: 4.492

Review 6.  A role for sigma receptors in stimulant self-administration and addiction.

Authors:  Jonathan L Katz; Weimin C Hong; Takato Hiranita; Tsung-Ping Su
Journal:  Behav Pharmacol       Date:  2016-04       Impact factor: 2.293

7.  Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol.

Authors:  Jianjing Cao; Theresa Kopajtic; Jonathan L Katz; Amy Hauck Newman
Journal:  Bioorg Med Chem Lett       Date:  2008-08-22       Impact factor: 2.823

8.  Resting-State Functional Connectivity between Putamen and Salience Network and Childhood Body Mass Index.

Authors:  Shervin Assari; Shanika Boyce
Journal:  Neurol Int       Date:  2021-03-04
  8 in total

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