K Christman1, D Kelsen, L Saltz, P G Tarassoff. 1. Department of Medicine, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College, New York, New York.
Abstract
BACKGROUND: Approximately 22,000 new cases of gastric cancer are diagnosed each year in the United States, most of which are advanced disease and thus are not curable by surgery. Chemotherapy has had little impact on patient survival. Consequently, the evaluation of new agents is needed. Gemcitabine, a cytosine arabinoside analogue, was evaluated in a Phase II trial to assess its efficacy in previously untreated patients with advanced gastric cancer. METHODS: Patients were treated with weekly gemcitabine, 800 mg/m2, for 3 consecutive weeks, followed by a 1-week rest period. Eighteen patients were enrolled. Fifteen patients were evaluable for response; 2 patients refused therapy before the completion of one cycle of treatment, and one patient was found to have nonmeasurable disease. RESULTS: No major objective responses were seen. Two minor responses occurred. One patient with a minor response was removed from the study at his request after ten cycles of treatment. The other patient remains on the study with stable disease at more than 17 months. Toxicities on this study were mild. Median leukocyte count and platelet nadirs were 5.0 (range, 2.2-51.0) and 234,000/microliters (range, 59,000-554,000/microliters), respectively. CONCLUSION: Gemcitabine at this dose and schedule has no significant antitumor activity in gastric cancer.
BACKGROUND: Approximately 22,000 new cases of gastric cancer are diagnosed each year in the United States, most of which are advanced disease and thus are not curable by surgery. Chemotherapy has had little impact on patient survival. Consequently, the evaluation of new agents is needed. Gemcitabine, a cytosine arabinoside analogue, was evaluated in a Phase II trial to assess its efficacy in previously untreated patients with advanced gastric cancer. METHODS:Patients were treated with weekly gemcitabine, 800 mg/m2, for 3 consecutive weeks, followed by a 1-week rest period. Eighteen patients were enrolled. Fifteen patients were evaluable for response; 2 patients refused therapy before the completion of one cycle of treatment, and one patient was found to have nonmeasurable disease. RESULTS: No major objective responses were seen. Two minor responses occurred. One patient with a minor response was removed from the study at his request after ten cycles of treatment. The other patient remains on the study with stable disease at more than 17 months. Toxicities on this study were mild. Median leukocyte count and platelet nadirs were 5.0 (range, 2.2-51.0) and 234,000/microliters (range, 59,000-554,000/microliters), respectively. CONCLUSION:Gemcitabine at this dose and schedule has no significant antitumor activity in gastric cancer.
Authors: John T Miura; Joanne Xiu; James Thomas; Ben George; Benjamin R Carron; Susan Tsai; Fabian M Johnston; Kiran K Turaga; T Clark Gamblin Journal: Cancer Biol Ther Date: 2015-03-16 Impact factor: 4.742
Authors: Roxana Cristina Popescu; Ecaterina Andronescu; Bogdan Ștefan Vasile; Roxana Truşcă; Adina Boldeiu; Laurențiu Mogoantă; George Dan Mogoșanu; Mihaela Temelie; Mihai Radu; Alexandru Mihai Grumezescu; Diana Savu Journal: Molecules Date: 2017-06-28 Impact factor: 4.411