Literature DB >> 8275319

Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain.

M Sarder1, H Saito, K Abe.   

Abstract

We investigated the effects of interleukin-2 (IL-2) on the survival and morphology of primary cultured neurons from fetal rat brain. Addition of recombinant human IL-2 significantly supported the survival of brain neurons in high cell density culture, but did not show any effect on the neuronal survival in low cell density culture. In addition, IL-2 significantly promoted the neurite elongation and branching of hippocampal neurons in low cell density culture. These results suggest that IL-2 supports neuronal survival indirectly and promotes neuritogenesis by directly acting on brain neurons.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8275319     DOI： 10.1016/0006-8993(93)91080-c

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  Loss of cholinergic phenotype in septohippocampal projection neurons: relation to brain versus peripheral IL-2 deficiency.

Authors:  Danielle M Meola; Zhi Huang; Michael King; John M Petitto
Journal:  Neurosci Lett       Date:  2013-02-13       Impact factor: 3.046

2.  Loss of Neuronal Phenotype and Neurodegeneration: Effects of T Lymphocytes and Brain Interleukin-2.

Authors:  Danielle Meola; Zhi Huang; Grace K Ha; John M Petitto
Journal:  J Alzheimers Dis Parkinsonism       Date:  2013-06

3.  5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.

Authors:  Thomas R Groves; Ryan Farris; Julie E Anderson; Tyler C Alexander; Frederico Kiffer; Gwendolyn Carter; Jing Wang; Marjan Boerma; Antiño R Allen
Journal:  Behav Brain Res       Date:  2016-09-04       Impact factor: 3.332

4.  Increased Retinal Ganglion Cell Survival by Exogenous IL-2 Depends on IL-10, Dopamine D1 Receptors, and Classical IL-2/IL-2R Signaling Pathways.

Authors:  Tamiris Gago Colares; Camila Saggioro de Figueiredo; Lucienne de Oliveira Jesus Souza; Aline Araujo Dos Santos; Elizabeth Giestal-de-Araujo
Journal:  Neurochem Res       Date:  2021-04-01       Impact factor: 3.996

5.  Interleukin-2 deficiency-induced T cell autoimmunity in the mouse brain.

Authors:  Zhi Huang; Daniel J Dauer; Grace K Ha; Mark H Lewis; John M Petitto
Journal:  Neurosci Lett       Date:  2009-07-10       Impact factor: 3.046

6.  Effects of Brain-Derived IL-2 Deficiency and the Development of Autoimmunity on Spatial Learning and Fear Conditioning.

Authors:  John M Petitto; Jesse D Cushman; Zhi Huang
Journal:  J Neurol Disord       Date:  2015

7.  Selective Neuronal and Brain Regional Expession of IL-2 in IL2P 8-GFP Transgenic Mice: Relation to Sensorimotor Gating.

Authors:  Danielle Meola; Zhi Huang; John M Petitto
Journal:  J Alzheimers Dis Parkinsonism       Date:  2013-10-28

8.  Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming.

Authors:  Yiping Fan; Guillaume Marcy; Eddy S M Lee; Steve Rozen; Citra N Z Mattar; Simon N Waddington; Eyleen L K Goh; Mahesh Choolani; Jerry K Y Chan
Journal:  PLoS One       Date:  2014-09-02       Impact factor: 3.240

Review 9.  Neuro-endocrine networks controlling immune system in health and disease.

Authors:  Claudio Procaccini; Valentina Pucino; Veronica De Rosa; Gianni Marone; Giuseppe Matarese
Journal:  Front Immunol       Date:  2014-04-07       Impact factor: 7.561
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.