| Literature DB >> 8275059 |
E Mattsson1, L Verhage, J Rollof, A Fleer, J Verhoef, H van Dijk.
Abstract
Cytokines play a major role in the pathophysiology of septic shock. In this study, human peripheral blood monocytes were stimulated with peptidoglycan and teichoic acid, purified from a strain of Staphylococcus epidermidis. Polymyxin B (PM-B) was added to avoid the effects of possible contamination with endotoxin. Tumour necrosis factor-alpha (TNF), interleukin-1 beta (IL-1), and interleukin-6 (IL-6) in the supernates were measured by enzyme-linked immunosorbent assays. Peptidoglycan and teichoic acid induced TNF, IL-1, and IL-6 in a concentration-dependent manner. Teichoic acid was a weaker inducer than peptidoglycan, especially for IL-1. Lipopolysaccharide from an E. coli strain was used as a control, being 100-1000 times more potent than peptidoglycan and teichoic acid.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8275059 DOI： 10.1111/j.1574-695X.1993.tb00409.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244