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Literature DB >> 8274851

Mechanistic and structural complexity in the site-specific recombination pathways of Int and FLP.

Abstract

This review focuses on two of the approximately 30 members of the diverse Int family of site-specific recombinases. The lambda recombination system represents those reactions involving accessory proteins and a complex higher-order structure. The FLP system represents the most streamlined reactions and has been the subject of detailed and informative studies on the mechanisms of DNA cleavage and ligation.

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Year: 1993 PMID： 8274851 DOI： 10.1016/s0959-437x(05)80086-3

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

25 in total

1. DNA recognition, strand selectivity, and cleavage mode during integrase family site-specific recombination.

Authors: G Tribble; Y T Ahn; J Lee; T Dandekar; M Jayaram
Journal: J Biol Chem Date: 2000-07-21 Impact factor: 5.157

2. Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022.

Authors: M Kolot; N Silberstein; E Yagil
Journal: Mol Biol Rep Date: 1999-08 Impact factor: 2.316

3. Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity.

Authors: Kathy A Gelato; Shelley S Martin; Patty H Liu; April A Saunders; Enoch P Baldwin
Journal: J Mol Biol Date: 2008-03-04 Impact factor: 5.469

4. Recombination by resolvase to analyse DNA communications by the SfiI restriction endonuclease.

Authors: M D Szczelkun; S E Halford
Journal: EMBO J Date: 1996-03-15 Impact factor: 11.598

5. The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition.

Authors: S Y Namgoong; R M Harshey
Journal: EMBO J Date: 1998-07-01 Impact factor: 11.598

Mechanistic and structural complexity in the site-specific recombination pathways of Int and FLP.

1. DNA recognition, strand selectivity, and cleavage mode during integrase family site-specific recombination.

2. Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022.

3. Spatially directed assembly of a heterotetrameric Cre-Lox synapse restricts recombination specificity.

4. Recombination by resolvase to analyse DNA communications by the SfiI restriction endonuclease.

5. The same two monomers within a MuA tetramer provide the DDE domains for the strand cleavage and strand transfer steps of transposition.

6. Protein-DNA complexes in mycobacteriophage L5 integrative recombination.

7. Asymmetry in Flp-mediated cleavage.

8. Genetic analysis of the bacteriophage lambda attL nucleoprotein complex.

9. Action of site-specific recombinases XerC and XerD on tethered Holliday junctions.

10. The catalytic domain of lambda site-specific recombinase.