OBJECTIVE: To assess the role of concentrations of cytokines in peritoneal fluid in estimating the severity of the host's response to the stress of abdominal operations. DESIGN: Prospective study. SETTING: University hospital, Japan. SUBJECT: 49 patients who underwent various abdominal operations. Main outcome measures--Correlations between concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) in peritoneal fluid measured on the first postoperative day on the one hand, and peritoneal bacterial count, length of operation, and operative blood loss, on the other. RESULTS: The concentrations of all three peritoneal cytokines correlated significantly with length of operation; those of TNF-alpha and IL-1 beta also correlated significantly with peritoneal bacterial count, and that of IL-1 beta with operative blood loss. There were significant correlations between the concentrations of the three cytokines. CONCLUSION: These correlations suggest that monitoring of the peritoneal concentrations of TNF-alpha, IL-1 beta, and IL-6 may be helpful in estimating the severity of stress caused by abdominal operations.
OBJECTIVE: To assess the role of concentrations of cytokines in peritoneal fluid in estimating the severity of the host's response to the stress of abdominal operations. DESIGN: Prospective study. SETTING: University hospital, Japan. SUBJECT: 49 patients who underwent various abdominal operations. Main outcome measures--Correlations between concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) in peritoneal fluid measured on the first postoperative day on the one hand, and peritoneal bacterial count, length of operation, and operative blood loss, on the other. RESULTS: The concentrations of all three peritoneal cytokines correlated significantly with length of operation; those of TNF-alpha and IL-1 beta also correlated significantly with peritoneal bacterial count, and that of IL-1 beta with operative blood loss. There were significant correlations between the concentrations of the three cytokines. CONCLUSION: These correlations suggest that monitoring of the peritoneal concentrations of TNF-alpha, IL-1 beta, and IL-6 may be helpful in estimating the severity of stress caused by abdominal operations.
Authors: Pedro Moya; Elena Miranda; Leticia Soriano-Irigaray; Antonio Arroyo; Maria-Del-Mar Aguilar; Marta Bellón; Jose-Luis Muñoz; Fernando Candela; Rafael Calpena Journal: Surg Endosc Date: 2016-03-02 Impact factor: 4.584
Authors: W M U van Grevenstein; L J Hofland; M E E van Rossen; P M van Koetsveld; J Jeekel; C H J van Eijck Journal: Dig Dis Sci Date: 2007-03-30 Impact factor: 3.199
Authors: M K Whitworth; A Sheen; D D Rosa; S E Duff; D Ryder; A Burumdayal; K Wiener; R E Hawkins; M Saunders; J W Valle; D Sherlock; G C Jayson Journal: J Cancer Res Clin Oncol Date: 2005-10-26 Impact factor: 4.553