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Literature DB >> 8274190

Role of heparan sulfate in immune system-blood vessel interactions.

N S Ihrcke¹, L E Wrenshall, B J Lindman, J L Platt.

Abstract

Heparan sulfate proteoglycan, a component of endothelial cell membranes and extracellular matrices, is involved in a number of the critical functions of endothelium and of antigen-presenting cells. This review discusses how heparan sulfate is released from endothelial cells during inflammation, how the loss of heparan sulfate potentially alters endothelial cell physiology, and how the presence of heparan sulfate in a soluble form might regulate the functioning of lymphocytes at sites of inflammation.

Entities: Chemical Disease Gene

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Year: 1993 PMID： 8274190 DOI： 10.1016/0167-5699(93)90265-M

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

52 in total

1. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.

Authors: Sara Massena; Gustaf Christoffersson; Elina Hjertström; Eyal Zcharia; Israel Vlodavsky; Nora Ausmees; Charlotte Rolny; Jin-Ping Li; Mia Phillipson
Journal: Blood Date: 2010-06-08 Impact factor: 22.113

2. Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.

Authors: Matthew Ndonwi; Oname O Burlingame; Aaron S Miller; Douglas M Tollefsen; George J Broze; Daniel E Goldberg
Journal: Blood Date: 2011-04-21 Impact factor: 22.113

3. Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix.

Authors: R Hershkoviz; H Schor; A Ariel; I Hecht; I R Cohen; O Lider; L Cahalon
Journal: Immunology Date: 2000-01 Impact factor: 7.397

4. Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.

Authors: Meini Wu; Haixuan Wang; Jiandong Shi; Jing Sun; Zhiqing Duan; Yanhan Li; Jianfang Li; Ningzhu Hu; Yiju Wei; Yang Chen; Yunzhang Hu
Journal: Hum Vaccin Immunother Date: 2014 Impact factor: 3.452

Role of heparan sulfate in immune system-blood vessel interactions.

1. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils.

2. Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.

3. Disaccharides generated from heparan sulphate or heparin modulate chemokine-induced T-cell adhesion to extracellular matrix.

4. Gene expression profiles identify both MyD88-independent and MyD88-dependent pathways involved in the maturation of dendritic cells mediated by heparan sulfate: a novel adjuvant.

Review 5. The endothelial glycocalyx: composition, functions, and visualization.

Review 6. Recent advances in the immunology of xenotransplantation.

Review 7. The endothelial glycocalyx as a barrier to leukocyte adhesion and its mediation by extracellular proteases.

8. Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response.

9. Constitutive repression of interleukin-1alpha in endothelial cells.

Review 10. The role of antibodies in transplantation.