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Literature DB >> 8274187

Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?

Abstract

Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.

Entities: Disease Gene Species

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Year: 1993 PMID： 8274187 DOI： 10.1016/0167-5699(93)90259-n

Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699

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Cited

8 in total

1. Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library.

Authors: Peter Ellmark; Camilla Ottosson; Carl A K Borrebaeck; Ann-Christin Malmborg Hager; Christina Furebring
Journal: Immunology Date: 2002-08 Impact factor: 7.397

2. Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

Authors: Omid Haji-Ghassemi; Sven Müller-Loennies; Radka Saldova; Mohankumar Muniyappa; Lore Brade; Pauline M Rudd; David J Harvey; Paul Kosma; Helmut Brade; Stephen V Evans
Journal: J Biol Chem Date: 2014-03-28 Impact factor: 5.157

3. The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein.

Authors: Trish Benton; Tim Chen; Michele McEntee; Brian Fox; David King; Robert Crombie; Thomas C Thomas; Christopher Bebbington
Journal: Cytotechnology Date: 2002-01 Impact factor: 2.058

4. On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.

Authors: Thomas A E Platts-Mills; Scott P Commins; Tilo Biedermann; Marianne van Hage; Michael Levin; Lisa A Beck; Maria Diuk-Wasser; Uta Jappe; Danijela Apostolovic; Michael Minnicozzi; Marshall Plaut; Jeffrey M Wilson
Journal: J Allergy Clin Immunol Date: 2020-02-10 Impact factor: 10.793

5. Glycosylation profiles of epitope-specific anti-beta-amyloid antibodies revealed by liquid chromatography-mass spectrometry.

Authors: Irina Perdivara; Leesa J Deterding; Claudia Cozma; Kenneth B Tomer; Michael Przybylski
Journal: Glycobiology Date: 2009-03-24 Impact factor: 4.313

Does endogenous glycosylation prevent the use of mouse monoclonal antibodies as cancer therapeutics?

1. Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library.

2. Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

3. The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein.

4. On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.

5. Glycosylation profiles of epitope-specific anti-beta-amyloid antibodies revealed by liquid chromatography-mass spectrometry.

Review 6. Updates in the Development of ImmunoRNases for the Selective Killing of Tumor Cells.

Review 7. Transgenic milk as a method for the production of recombinant antibodies.

Review 8. Fc glycans of therapeutic antibodies as critical quality attributes.