| Literature DB >> 8273584 |
K I Hulkower1, J W Coffey, W Levin, C M Anderson, T Chen, W C Hope, D R Bolin, D W Morgan.
Abstract
We investigated the temporal relationship between the increase in enzymatic activity and protein of a high molecular weight (100 kDa), cytosolic PLA2 (cPLA2) in interleukin-1 beta (IL-1 beta)-treated rheumatoid synovial fibroblasts (RSF). Both of these responses increased according to a similar time-course which correlates with PGE2 production by these cells. In contrast, 14 kDa, secreted PLA2 (sPLA2), which was also produced by RSF, was not affected by IL-1 beta treatment. These findings support that an augmentation of CPLA2 activity, caused by an induction of cPLA2 protein, rather than sPLA2, is temporally associated with increased PGE2 production in IL-1 beta-treated RSF.Entities:
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Year: 1993 PMID： 8273584 DOI： 10.1007/bf01972703
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299