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Literature DB >> 8273513

Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.

J R Chowdhury¹, R Kondapalli, N R Chowdhury.

Abstract

Experiments in Gunn rats have provided important insights into physiological, biochemical, and molecular mechanisms of bilirubin conjugation and disposition. The Gunn rat is a natural model for bilirubin encephalopathy, and much of our knowledge of bilirubin toxicity and its treatment has come from studies performed in Gunn rats. The genetic lesion in Gunn rats closely parallel those in Crigler-Najjar syndrome, Type I. Presently, the Gunn rat model is being used to develop methods for gene therapy for inherited bilirubin-UGT deficiency. Thus, Gunn rats continue to be a valuable model for the investigation of inherited UGT deficiency and severe nonhemolytic unconjugated hyperbilirubinemia.

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Year: 1993 PMID： 8273513

Source DB: PubMed Journal: Adv Vet Sci Comp Med ISSN： 0065-3519

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Cited

18 in total

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Review 2. Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells.

Authors: Chen Chen; Alejandro Soto-Gutierrez; Pedro M Baptista; Bart Spee
Journal: Gastroenterology Date: 2018-02-08 Impact factor: 22.682

3. Bilirubin Encephalopathy in a Domestic Shorthair Cat With Increased Osmotic Fragility and Cholangiohepatitis.

Authors: E T Contreras; U Giger; J L Malmberg; J M Quimby; P A Schaffer
Journal: Vet Pathol Date: 2015-09-09 Impact factor: 2.221

4. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.

Authors: Ioannis Papageorgiou; Marina Freytsis; Michael H Court
Journal: Biochem Pharmacol Date: 2016-08-13 Impact factor: 5.858

10. Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities.

Authors: Stephen W J Wang; Kaustubh H Kulkarni; Lan Tang; Jing Rong Wang; Taijun Yin; Tomo Daidoji; Hiroshi Yokota; Ming Hu
Journal: J Pharmacol Exp Ther Date: 2009-03-05 Impact factor: 4.030

Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.

1. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Review 2. Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells.

3. Bilirubin Encephalopathy in a Domestic Shorthair Cat With Increased Osmotic Fragility and Cholangiohepatitis.

4. Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver.

5. Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat.

6. Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity.

7. Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine.

8. Microfluidic photoreactor to treat neonatal jaundice.

9. The use of jejunal transplants to treat a genetic enzyme deficiency.

10. Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities.