Literature DB >> 8273152

Synthetic enhancement in gene interaction: a genetic tool come of age.

L Guarente1.   

Abstract

Synthetic enhancement, in which one mutation exacerbates the severity of another, is a genetic interaction of increasing importance in biology. This review focuses on the logic of interpreting synthetic enhancement, and begins by comparing the phenomenon with genetic suppression.

Mesh：

Year:  1993        PMID： 8273152     DOI： 10.1016/0168-9525(93)90042-g

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  108 in total

1.  Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria.

Authors:  Q Tan; K L Linask; R H Ebright; N A Woychik
Journal:  Genes Dev       Date:  2000-02-01       Impact factor: 11.361

2.  Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking.

Authors:  C R Harris; T J Silhavy
Journal:  J Bacteriol       Date:  1999-06       Impact factor: 3.490

3.  The yeast pafl-rNA polymerase II complex is required for full expression of a subset of cell cycle-regulated genes.

Authors:  Stephanie E Porter; Taylor M Washburn; Meiping Chang; Judith A Jaehning
Journal:  Eukaryot Cell       Date:  2002-10

4.  Trichome cell growth in Arabidopsis thaliana can be derepressed by mutations in at least five genes.

Authors:  D Perazza; M Herzog; M Hülskamp; S Brown; A M Dorne; J M Bonneville
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

Review 5.  An intermittent approach for cancer chemoprevention.

Authors:  Xiangwei Wu; Scott M Lippman
Journal:  Nat Rev Cancer       Date:  2011-11-10       Impact factor: 60.716

6.  Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae.

Authors:  Stephanie Smith; Ji-Young Hwang; Soma Banerjee; Anju Majeed; Amitabha Gupta; Kyungjaem Myung
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-07       Impact factor: 11.205

7.  The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae.

Authors:  Bernhard Suter; Amy Tong; Michael Chang; Lisa Yu; Grant W Brown; Charles Boone; Jasper Rine
Journal:  Genetics       Date:  2004-06       Impact factor: 4.562

8.  In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer.

Authors:  Sukesh R Bhaumik; Tamal Raha; David P Aiello; Michael R Green
Journal:  Genes Dev       Date:  2004-02-01       Impact factor: 11.361

9.  Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.

Authors:  Dagmar Bacíková; David S Horowitz
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

10.  Regulatory hierarchy of photomorphogenic loci: allele-specific and light-dependent interaction between the HY5 and COP1 loci.

Authors:  L H Ang; X W Deng
Journal:  Plant Cell       Date:  1994-05       Impact factor: 11.277
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