Literature DB >> 827311

Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A23187.

W C Pickett, R L Jesse, P Cohen.   

Abstract

Phospholipase A2 activity in a suspension of intact platelets was induced by addition of a Ca2+-ionophore, A23187. This action of ionophore A23187 was enhanced by EGTA and inhibited by an excess of Ca2+ in the medium, findings which suggest that A23187 is able to mobilize intracellular Ca2+ for the latter's role as an essential cofactor for phospholipase A2 activity.

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Year:  1976        PMID： 827311     DOI： 10.1016/0005-2760(77)90086-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  31 in total

1.  Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets.

Authors:  E G Lapetina; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

2.  Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen.

Authors:  W K Pollock; T J Rink; R F Irvine
Journal:  Biochem J       Date:  1986-05-01       Impact factor: 3.857

3.  Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

Authors:  E G Lapetina; K A Chandrabose; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

4.  Regulation of phosphatidylinositol turnover, calcium metabolism and enzyme secretion by phorbol dibutyrate in neutrophils.

Authors:  C M Kramer; R C Franson; R P Rubin
Journal:  Lipids       Date:  1984-05       Impact factor: 1.880

5.  Marked increase of human platelet phospholipase A2 activity in vitro and demonstration of an endogenous inhibitor.

Authors:  L R Ballou; W Y Cheung
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

6.  Effects of calcitriol on stimulation of ion transport in pig jejunal mucosa.

Authors:  B Schröder; R Kaune; J Harmeyer
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

7.  Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.

Authors:  W R Henderson; J B Harley; A S Fauci
Journal:  Immunology       Date:  1984-04       Impact factor: 7.397

8.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.

Authors:  P Borgeat; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

9.  Phospholipid metabolism in stimulated human platelets. Changes in phosphatidylinositol, phosphatidic acid, and lysophospholipids.

Authors:  M J Broekman; J W Ward; A J Marcus
Journal:  J Clin Invest       Date:  1980-08       Impact factor: 14.808

10.  Roles of Ca2+ and protein kinase C in regulation of prostaglandin E2 release by cultured rabbit gastric epithelial cells.

Authors:  S Ota; Y Hata; A Terano; K Yoshiura; H Hiraishi; T Kawabe; H Mutoh; S Shiina; T Sugimoto
Journal:  Dig Dis Sci       Date:  1993-08       Impact factor: 3.199
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