Literature DB >> 827290

Trypsin-induced phospholipase activity in human platelets.

W C Pickett, R L Jesse, P Cohen.   

Abstract

Trypsin mediates a release of arachidonic acid with resultant increase in O2 consumption (a reflection of cyclo-oxygenase activity) by whole human platelets that is similar to thrombin's effect on these cells. The trypsin and thrombin effects can be differentiated in two ways: (1) at saturating concentrations the measured effects of trypsin greatly exceed those of thrombin; (2) EGTA [ethanedioxybis(ethylamine)-NNN'N'-tera-acetate] augments the effect of thrombin but not of trypsin. Thus trypsin and thrombin probably act at different loci in the pathway that induces phospholipase activity in human platelets.

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Year:  1976        PMID： 827290      PMCID： PMC1164248          DOI： 10.1042/bj1600405

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Reversible alterations in platelet morphology produced by anticoagulants and by cold.

Authors:  M B ZUCKER; J BORRELLI
Journal:  Blood       Date:  1954-06       Impact factor: 22.113

2.  Patterns of fatty acid release from endogenous substrates by human platelet homogenates and membranes.

Authors:  A Derksen; P Cohen
Journal:  J Biol Chem       Date:  1975-12-25       Impact factor: 5.157

3.  The binding of thrombin to the surface of human platelets.

Authors:  D M Tollefsen; J R Feagler; P W Majerus
Journal:  J Biol Chem       Date:  1974-04-25       Impact factor: 5.157

4.  [Action of blood platelets on plasma prophospholipase].

Authors:  M U Duchesne; J Etienne; A Grüber; J Polonovski
Journal:  Biochimie       Date:  1972       Impact factor: 4.079

5.  Changes in platelet volume produced by temperature, metabolic inhibitors, and aggregating agents.

Authors:  B S Bull; M B Zucker
Journal:  Proc Soc Exp Biol Med       Date:  1965-11

6.  Purification and properties of phospholipase A and its zymogen from porcine pancreas.

Authors:  G H de Haas; M M Postema; W Niewenhuizen; L L van Deenen
Journal:  Bull Soc Chim Biol (Paris)       Date:  1968-12

7.  Mechanism of the thrombin-mediated burst in oxygen consumption by human platelets.

Authors:  W C Pickett; P Cohen
Journal:  J Biol Chem       Date:  1976-04-25       Impact factor: 5.157

8.  Influence of medium tonicity on respiration by suspensions of human platelets.

Authors:  W C Pickett; P Cohen
Journal:  Am J Physiol       Date:  1976-07

9.  An improved method for isolating alpha granules and mitochondria from human platelets.

Authors:  M J Broekman; N P Westmoreland; P Cohen
Journal:  J Cell Biol       Date:  1974-02       Impact factor: 10.539
  9 in total
  11 in total

1.  Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets.

Authors:  E G Lapetina; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

2.  Primary role of calcium ions in arachidonic acid release from rat platelet membranes. Comparison with human platelet membranes.

Authors:  S Nakashima; A Suganuma; A Matsui; H Hattori; M Sato; A Takenaka; Y Nozawa
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857

3.  Role of calcium in prostaglandin E release induced by bradykinin and the ionophore A 23187.

Authors:  H Juan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-06       Impact factor: 3.000

Review 4.  Are phospholipases involved in platelet activation?

Authors:  G Bereziat
Journal:  Agents Actions       Date:  1979-10

5.  Utilization of membranous lipid substrates by membranous enzymes. Hydrolysis of sphingomyelin in erythrocyte 'ghosts' and liposomes by the membranous sphingomyelinase of chicken erythrocyte 'ghosts'.

Authors:  M Record; A Loyter; S Gatt
Journal:  Biochem J       Date:  1980-04-01       Impact factor: 3.857

Review 6.  Phospholipases, eicosanoid production and inflammation.

Authors:  J P Famaey
Journal:  Clin Rheumatol       Date:  1982-06       Impact factor: 2.980

7.  Mechanism of action of bradykinin-induced release of prostaglandin E.

Authors:  H Juan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-10       Impact factor: 3.000

8.  Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids.

Authors:  G J Blackwell; R J Flower; F P Nijkamp; J R Vane
Journal:  Br J Pharmacol       Date:  1978-01       Impact factor: 8.739

9.  Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching.

Authors:  R H Smith; R M Palmer; P J Reeds
Journal:  Biochem J       Date:  1983-07-15       Impact factor: 3.857

10.  Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187.

Authors:  B B Weksler; C W Ley; E A Jaffe
Journal:  J Clin Invest       Date:  1978-11       Impact factor: 14.808
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