| Literature DB >> 8272871 |
C H Bassing1, J M Yingling, D J Howe, T Wang, W W He, M L Gustafson, P Shah, P K Donahoe, X F Wang.
Abstract
Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.Entities:
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Year: 1994 PMID： 8272871 DOI： 10.1126/science.8272871
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728