Literature DB >> 8272869

Mitotic repression of RNA polymerase III transcription in vitro mediated by phosphorylation of a TFIIIB component.

J M Gottesfeld1, V J Wolf, T Dang, D J Forbes, P Hartl.   

Abstract

Interphase cytosol extracts prepared from Xenopus laevis eggs are active in RNA polymerase III (Pol III) transcription. Addition of recombinant B1 cyclin to these extracts activates mitotic protein kinases that repress transcription. Affinity-purified p34cdc2-cyclin B kinase (mitosis-promoting factor) is sufficient to effect this repression in a simplified Pol III transcription system. This mitotic repression involves the direct phosphorylation of a component of the Pol III transcription initiation factor TFIIIB, which consists of the TATA box-binding protein (TBP) and associated Pol III-specific factors. The transcriptional activity of the TFIIIB-TBP fraction can be modulated in vitro by phosphorylation with mitotic kinases and by dephosphorylation with immobilized alkaline phosphatase.

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Year:  1994        PMID： 8272869     DOI： 10.1126/science.8272869

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  63 in total

1.  A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition.

Authors:  A Dey; J Ellenberg; A Farina; A E Coleman; T Maruyama; S Sciortino; J Lippincott-Schwartz; K Ozato
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

Review 2.  RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.

Authors:  T R Brown; P H Scott; T Stein; A G Winter; R J White
Journal:  Gene Expr       Date:  2000

3.  Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes.

Authors:  Romi Ghose; Mariam Malik; Paul W Huber
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

4.  Hyperphosphorylation by cyclin B/CDK1 in mitosis resets CUX1 DNA binding clock at each cell cycle.

Authors:  Laurent Sansregret; David Gallo; Marianne Santaguida; Lam Leduy; Ryoko Harada; Alain Nepveu
Journal:  J Biol Chem       Date:  2010-08-19       Impact factor: 5.157

5.  Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax protein.

Authors:  J M Gottesfeld; D L Johnson; J K Nyborg
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

6.  Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae.

Authors:  K Pluta; O Lefebvre; N C Martin; W J Smagowicz; D R Stanford; S R Ellis; A K Hopper; A Sentenac; M Boguta
Journal:  Mol Cell Biol       Date:  2001-08       Impact factor: 4.272

7.  TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.

Authors:  Jennifer A Fairley; Pamela H Scott; Robert J White
Journal:  EMBO J       Date:  2003-11-03       Impact factor: 11.598

8.  Partially processed pre-rRNA is preserved in association with processing components in nucleolus-derived foci during mitosis.

Authors:  M Dundr; M O Olson
Journal:  Mol Biol Cell       Date:  1998-09       Impact factor: 4.138

9.  Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.

Authors:  Sandra A S Johnson; Louis Dubeau; Deborah L Johnson
Journal:  J Biol Chem       Date:  2008-05-01       Impact factor: 5.157

Review 10.  RNA polymerase III repression by the retinoblastoma tumor suppressor protein.

Authors:  Alison Gjidoda; R William Henry
Journal:  Biochim Biophys Acta       Date:  2012-10-12
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