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Literature DB >> 827272

[Antifertility effect of an active immunization of monkeys with human pregnancy-specific beta 1-glycoprotein (SP1) (author's transl)].

Abstract

Fertile female cynomolgus monkeys (Macaca fascicularis) were actively immunized against human pregnancy-specific beta 1-glycoprotein (SP1). Native SP1 as well as chemically modified derivatives of SP1 served as antigens. The effect of the immunization on reproduction in these animals was investigated. The immunized monkeys showed a significant reduction in fertility: the conception rate in these animals was only slightly reduced when compared with the controls; but in the immunized monkeys pregnancy often resulted in abortion. The possibility of using immunization against SP1 as a contraceptive method in man is discussed.

Entities: Disease Gene Species

Keywords: Abortifacient Agents; Abortion, Drug Induced; Abortion, Induced; Abortion, Spontaneous; Animals, Laboratory; Antibodies; Biology; Clinical Research; Contraception; Contraception, Immunological; Contraceptive Effectiveness; Diseases; Family Planning; Fertility Control, Postconception; Hematological Effects; Hemic System; Immunity; Immunoglobulin Alterations; Immunologic Factors; Physiology; Pregnancy Complications; Research Methodology; Use-effectiveness

Mesh：

Substances：
Glycoproteins

Year: 1976 PMID： 827272 DOI： 10.1007/BF00667024

Source DB: PubMed Journal: Arch Gynakol ISSN： 0003-9128

20 in total

1. THE IMMUNE RESPONSE TO AZO-PROTEIN CONJUGATES IN RABBITS UNRESPONSIVE TO THE PROTEIN CARRIERS.

Authors: D NACHTIGAL; M FELDMAN
Journal: Immunology Date: 1964-11 Impact factor: 7.397

2. [Immunological disruption of implantation in monkeys with antibodies to human pregnancy specific beta 1-glycoprotein (SP1) (author's transl)].

Authors: H Bohn; E Weinmann
Journal: Arch Gynakol Date: 1974

3. Immunochemical determination of human pregnancy proteins.

Authors: H Bohn
Journal: Arch Gynakol Date: 1974

4. [Immunochemical identification of beta1-globulin of the "pregnancy zone" in serum of patients with trophoblastic tumors].

Authors: Y S Tatarinov; N V Mesnyankina; D M Nikoulina; L A Novikova; B O Toloknov; D M Falaleeva
Journal: Int J Cancer Date: 1974-10-15 Impact factor: 7.396

5. [Characterization of pregnancy-associated glycoproteins as acute phase proteins. Their demonstration in serums of patients with neoplasms and other diseases].

Authors: H Bohn
Journal: Arch Gynakol Date: 1972

6. Serum levels of a placental protein during gestation in the baboon.

Authors: V C Stevens; H Bohn; J E Powell
Journal: Am J Obstet Gynecol Date: 1976-01-01 Impact factor: 8.661

7. The effect of cross-reacting antigens on the tolerant state.

Authors: B Cinader; J E St Rose; M Yoshimura
Journal: J Exp Med Date: 1967-06-01 Impact factor: 14.307

8. [Detection and characterization of pregnancy proteins in the human placenta and their quantitative immunochemical determination in sera from pregnant women].

Authors: H Bohn
Journal: Arch Gynakol Date: 1971-10-28

9. THE INDUCTION OF AUTOIMMUNITY IN RABBITS FOLLOWING INJECTION OF HETEROLOGOUS OR ALTERED HOMOLOGOUS THYROGLOBULIN.

Authors: W O WEIGLE
Journal: J Exp Med Date: 1965-02-01 Impact factor: 14.307

10. Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens.

Authors: W O WEIGLE
Journal: J Exp Med Date: 1962-12-01 Impact factor: 14.307

4 in total