Literature DB >> 8271272

Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl- efflux.

T Mastrocola1, I H Lambert, B Kramhøft, M Rugolo, E K Hoffmann.   

Abstract

Trypsinized human skin fibroblasts in suspension perform regulatory volume decrease (RVD) after cell swelling in hypotonic medium. During RVD, 36Cl- efflux is dramatically increased and the cell membrane is depolarized, indicating the activation of Cl- channels. This activation of Cl- channels depends on extracellular as well as on intracellular Ca2+. The swelling-induced Cl- efflux and the RVD response are inhibited by the 5-lipoxygenase inhibitor ETH 615-139. Finally, following hypotonic treatment, cellular pH decreases. The pH decrease does not involve the Cl-/HCO3- exchange because it is independent of the external Cl- concentration.

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Year:  1993        PMID： 8271272     DOI： 10.1007/bf00241489

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  29 in total

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Authors:  I H Lambert; E K Hoffmann; P Christensen
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3.  Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?

Authors:  J B Lansman; T J Hallam; T J Rink
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6.  Mediation of cell volume regulation by Ca2+ influx through stretch-activated channels.

Authors:  O Christensen
Journal:  Nature       Date:  1987 Nov 5-11       Impact factor: 49.962

7.  Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.

Authors:  I H Lambert
Journal:  J Membr Biol       Date:  1989-05       Impact factor: 1.843

8.  Hypotonic shock activated Cl- and K+ pathways in human fibroblasts.

Authors:  T Mastrocola; A Flamigni; M Rugolo
Journal:  Biochim Biophys Acta       Date:  1991-11-04

9.  Cell swelling activates K+ and Cl- channels as well as nonselective, stretch-activated cation channels in Ehrlich ascites tumor cells.

Authors:  O Christensen; E K Hoffmann
Journal:  J Membr Biol       Date:  1992-07       Impact factor: 1.843

10.  Volume-induced increase of anion permeability in human lymphocytes.

Authors:  S Grinstein; C A Clarke; A Dupre; A Rothstein
Journal:  J Gen Physiol       Date:  1982-12       Impact factor: 4.086
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  8 in total

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6.  Swelling of rat mesangial cells induces a Ca2+-dependent Cl- conductance.

Authors:  H Pavenstädt; M Huber; K G Fischer; J Gloy; J Leipziger; P Schollmeyer; R Greger
Journal:  Pflugers Arch       Date:  1996-03       Impact factor: 3.657

7.  Hypotonically activated chloride current in HSG cells.

Authors:  S Fatherazi; K T Izutsu; R B Wellner; C M Belton
Journal:  J Membr Biol       Date:  1994-11       Impact factor: 1.843

8.  Enhancement of iron toxicity in L929 cells by D-glucose: accelerated(re-)reduction.

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  8 in total

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