Literature DB >> 8270972

Transdermal clonidine for ameliorating tamoxifen-induced hot flashes.

R M Goldberg1, C L Loprinzi, J R O'Fallon, M H Veeder, A W Miser, J A Mailliard, J C Michalak, A M Dose, K M Rowland, N L Burnham.   

Abstract

PURPOSE: To determine the efficacy of transdermal clonidine for alleviating tamoxifen-induced hot flashes in women with a history of breast cancer. PATIENTS AND METHODS: A randomized, double-blind, crossover design was used in this prospective study. Women with a history of breast cancer who were receiving tamoxifen and suffering from hot flashes were potentially eligible for this protocol study.
RESULTS: Clonidine did reduce hot-flash frequency to a degree that was statistically impressive (P < .0001), but clinically moderate (20% reduction from baseline). It also decreased hot-flash severity (P = .02, 10% reduction from baseline). Clonidine was related to increased mouth dryness (P < .001), constipation (P < .02), itchiness under the patch (P < .01), and drowsiness (P < .05).
CONCLUSION: Better means are needed to alleviate hot flashes among patients in whom estrogen therapy is contraindicated.

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Year:  1994        PMID： 8270972     DOI： 10.1200/JCO.1994.12.1.155

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN： 0732-183X            Impact factor:   44.544


  43 in total

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Review 2.  Therapy for menopausal symptoms during and after treatment for breast cancer : safety considerations.

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3.  Randomized trial of a hypnosis intervention for treatment of hot flashes among breast cancer survivors.

Authors:  Gary Elkins; Joel Marcus; Vered Stearns; Michelle Perfect; M Hasan Rajab; Christopher Ruud; Lynne Palamara; Timothy Keith
Journal:  J Clin Oncol       Date:  2008-09-22       Impact factor: 44.544

4.  Management of Potential Long-Term Toxicities in Breast Cancer Patients.

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5.  Feasibility study of acupuncture for reducing sleep disturbances and hot flashes in postmenopausal breast cancer survivors.

Authors:  Julie L Otte; Janet S Carpenter; Xin Zhong; Peter A S Johnstone
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6.  How are Interactions Taken into Account in Studies on Conventional and Complementary Therapies for Breast Cancer Patients with Menopausal Complaints?

Authors:  J Hübner; K Münstedt; R Mücke; O Micke
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7.  Phase III, randomized, double-blind, placebo-controlled evaluation of pregabalin for alleviating hot flashes, N07C1.

Authors:  Charles L Loprinzi; Rui Qin; Ernie P Balcueva; Ernie P Baclueva; Kathleen A Flynn; Kendrith M Rowland; David L Graham; Nancy K Erwin; Shaker R Dakhil; Donald J Jurgens; Kelli N Burger
Journal:  J Clin Oncol       Date:  2009-11-09       Impact factor: 44.544

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Authors:  Laura García-Estévez; Ignasi Tusquets; Isabel Alvarez; César Rodríguez; Yolanda Fernández; Miguel Angel Seguí; Jesús García-Mata; Ana Lluch
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9.  Management of hot flashes in women with breast cancer.

Authors:  L Kligman; J Younus
Journal:  Curr Oncol       Date:  2010-02       Impact factor: 3.677

10.  Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions.

Authors:  Deirdre R Pachman; Jason M Jones; Charles L Loprinzi
Journal:  Int J Womens Health       Date:  2010-08-09
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