Literature DB >> 8270494

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.

H Kakeya1, M Imoto, Y Takahashi, H Naganawa, T Takeuchi, K Umezawa.   

Abstract

Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was elucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chemical analyses of dephostatin and its derivatives.

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Year:  1993        PMID： 8270494     DOI： 10.7164/antibiotics.46.1716

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Effect of dephostatin on intracellular free calcium concentration and amylase secretion in isolated rat pancreatic acinar cells.

Authors:  A I Lajas; M J Pozo; P J Camello; G M Salido; J Singh; J A Pariente
Journal:  Mol Cell Biochem       Date:  2000-02       Impact factor: 3.396

2.  First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Authors:  Ming Li; Shivender M D Shandilya; Michael A Carpenter; Anurag Rathore; William L Brown; Angela L Perkins; Daniel A Harki; Jonathan Solberg; Derek J Hook; Krishan K Pandey; Michael A Parniak; Jeffrey R Johnson; Nevan J Krogan; Mohan Somasundaran; Akbar Ali; Celia A Schiffer; Reuben S Harris
Journal:  ACS Chem Biol       Date:  2012-01-17       Impact factor: 5.100

3.  A combined experimental and DFT mechanistic study for the unexpected nitrosolysis of N-hydroxymethyldialkylamines in fuming nitric acid.

Authors:  Yu Zhang; Po Zou; Yingbin Han; Yongliang Geng; Jun Luo; Baojing Zhou
Journal:  RSC Adv       Date:  2018-05-24       Impact factor: 4.036

4.  Methylnaltrexone potentiates the anti-angiogenic effects of mTOR inhibitors.

Authors:  Patrick A Singleton; Nurbek Mambetsariev; Frances E Lennon; Biji Mathew; Jessica H Siegler; Liliana Moreno-Vinasco; Ravi Salgia; Jonathan Moss; Joe Gn Garcia
Journal:  J Angiogenes Res       Date:  2010-02-19

5.  Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases.

Authors:  Yanbao Xiong; Michael Murphy; Tissa T Manavalan; Goutham Pattabiraman; Fu Qiu; Hui-Hsin Chang; I-Cheng Ho; Andrei E Medvedev
Journal:  J Innate Immun       Date:  2015-10-13       Impact factor: 7.349

6.  Literature mining for the discovery of hidden connections between drugs, genes and diseases.

Authors:  Raoul Frijters; Marianne van Vugt; Ruben Smeets; René van Schaik; Jacob de Vlieg; Wynand Alkema
Journal:  PLoS Comput Biol       Date:  2010-09-23       Impact factor: 4.475
  6 in total

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