Literature DB >> 8270262

Highly polymorphic repeat marker within the beta-amyloid precursor protein gene.

S Zappata1, M B Petersen, U König, J Blaschak, A Chakravarti, F Tassone, A Serra, S E Antonarakis, C Brahe.   

Abstract

We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the beta-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivs1, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.

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Year:  1994        PMID： 8270262     DOI： 10.1007/bf00218922

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  4 in total

1.  Framing beta-amyloid.

Authors:  J Hardy
Journal:  Nat Genet       Date:  1992-07       Impact factor: 38.330

2.  Potential gene sequence isolation and regional mapping in human chromosome 21.

Authors:  C Brahe; F Tassone; A Millington-Ward; A Serra; K Gardiner
Journal:  Am J Med Genet Suppl       Date:  1990

3.  Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.

Authors:  G La Fauci; D K Lahiri; S R Salton; N K Robakis
Journal:  Biochem Biophys Res Commun       Date:  1989-02-28       Impact factor: 3.575

4.  A linkage map of human chromosome 21:43 PCR markers at average intervals of 2.5 cM.

Authors:  M G McInnis; A Chakravarti; J Blaschak; M B Petersen; V Sharma; D Avramopoulos; J L Blouin; U König; C Brahe; T C Matise
Journal:  Genomics       Date:  1993-06       Impact factor: 5.736
  4 in total
  2 in total

1.  Novel mutations and repeated findings of mutations in familial Alzheimer disease.

Authors:  Ulrich Finckh; Christian Kuschel; Maria Anagnostouli; Efstratios Patsouris; George V Pantes; Stylianos Gatzonis; Elisabeth Kapaki; Panagiota Davaki; Katrin Lamszus; Dimitrios Stavrou; Andreas Gal
Journal:  Neurogenetics       Date:  2005-03-18       Impact factor: 2.660

2.  No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.

Authors:  D Campion; A Brice; D Hannequin; F Charbonnier; B Dubois; C Martin; A Michon; C Penet; M Bellis; A Calenda; M Martinez; Y Agid; F Clerget-Darpoux; T Frebourg
Journal:  J Med Genet       Date:  1996-08       Impact factor: 6.318
  2 in total

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